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Human FOXP3 Protein expressed in Wheat germ - ABIN1354393
Liu, Liu, Chen, Yang, Liu, Liu, Dugas, Tang, Zheng, Liu, Wang: FOXP3 Controls an miR-146/NF-?B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. in Cancer research 2015
Human FOXP3 Protein expressed in HEK-293 Cells - ABIN2721384
Larsen, Munir, Woetmann, Frøsig, Odum, Svane, Becker, Andersen: Functional characterization of Foxp3-specific spontaneous immune responses. in Leukemia 2013
analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish
correlation between the expression of t-bet, stat6 (show STAT6 Proteins) and foxp3 with other genes involved in Th and T(reg (show KCNH2 Proteins)) responses
cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals
Foxp3(+) cells in the brains of Multiple sclerosis patients predominantly produce interleukin-10 (IL-10 (show IL10 Proteins)) and show high expression of the IL-33 (show IL33 Proteins) receptor ST2 (show SULT2A1 Proteins).
Foxp3 expression is an unfavorable prognostic factor for disease progression in superficial bladder cancer patients
this review presents the existing data on FoxP3 expression in non-T-regulatory cells
Low-Foxp3/high-CD8 (show CD8A Proteins)+tumor infiltrating lymphocytes were associated with prolonged disease-free survival in stage I non-small cell lung carcinomas.
Control of Regulatory T Cell Development by the Transcription Factor Foxp3.
FOXP3 is regulated, at least in part, by the binding of p53 (show TP53 Proteins) to several binding sites in the promoter and intron regions following ultraviolet irradiation in psoriasis.
FOXP3 rs3761549 was significantly correlated with the renal allograft function.
the density of myocardial FoxP3+ cells early after heart transplantation appears to predict at least one measure of cardiac allograft vasculopathy burden after one year
Polymorphisms of FoxP3 rs5902434 and rs2232365 were associated with female recurrent respiratory papillomatosis in Koreans.
this paper reviews the role of FOXP3 in autoimmunity
Data suggest that genetic or environmental factors that even moderately affect the expression of both PD-1 (show PDCD1 Proteins) and FoxP3 can cause life-threatening autoimmune diseases by disrupting the T-cell homeostasis.
Foxp3 Programs the Development and Function of CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+ Regulatory T Cells.
An Essential Role for Scurfin in CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+ T Regulatory Cells.
Mechanistic analysis indicated that E47 (show TCF3 Proteins) activated expression of the transcription factor Spi-B (show SPIB Proteins) and the suppressor of cytokine signaling 3 (SOCS3 (show SOCS3 Proteins)), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 (show ID3 Proteins) and E47 (show TCF3 Proteins) controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity.
Foxp3 expression in lung epithelial cells, and not in Treg cells, inhibited OVA- and cockroach extract-induced asthma.
Regulatory T cells have a high apoptosis rate ex vivo correlating with low c-FLIP (show CFLAR Proteins) expression.
Forkhead box P3 protein (FoxP3) acts in multimodal fashion to directly activate or repress transcription, in a context- and partner-dependent manner, to govern Treg cell phenotypes.
Membrane-bound DKK-1 (show DKK1 Proteins) is a novel Foxp3 postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
A384T mutation associated with autoimmune IPEX syndrome, induces a distinctive tissue-restricted inflammation by specifically impairing the ability of Treg cells to compete with pathogenic T cells
sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids
In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection
GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4 (show CTLA4 Proteins).
The expression of Foxp3 in CD4 (show CD4 Proteins)(+) T cells from persistent lymphocytotic cattle was significantly increased.
There is a positive correlation between the intensity of CD25 (show IL2RA Proteins) expression and the expression of the transcription Foxp3 factor in bovine CD8 (show CD8A Proteins)(+) cells.
identification of Foxp3 expression in Treg cells
These findings revealed that despite the existence of a distinct bovine CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
The correlation of TH17-related TLR4 (show TLR4 Proteins) expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.
Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.
results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
forkhead box protein P3
, regulatory protein Foxp3
, forkhead box P3
, forkhead box protein P3-like
, transcription factor foxp3
, immune dysregulation, polyendocrinopathy, enteropathy, X-linked
, immunodeficiency, polyendocrinopathy, enteropathy, X-linked
, forkhead/winged helix transcription factor 3