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Biochemical analysis of the BAHD1 (show BAHD1 Antibodies)-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 (show BAHD1 Antibodies) and suggests that BAHD1 (show BAHD1 Antibodies)-MIER interaction forms a hub for histone deacetylases and methyltransferases
characterization of the mouse ortholog of mi-er1
XMI-ER1 is retained in the cytoplasm of the early embryo by interaction of the region containing amino acids 144-175 with a cytoplasmic anchor
Histone deacetylase (show HDAC1 Antibodies) assays confirmed that MIER2 (show MIER2 Antibodies), but not MIER3 (show MIER3 Antibodies) complexes, have associated deacetylase activity.
Insulin (show INS Antibodies) and IGF-1 (show IGF1 Antibodies) alter the subcellular localization of MIER1alpha in breast carcinoma cells.
nuclear targeting of MIER1alpha requires an intact ELM2 (show TENM4 Antibodies) domain and is dependent on interaction with HDAC1 (show HDAC1 Antibodies)/2
Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells
Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function.
we investigated the role of hMI-ER1alpha and hMI-ER1beta in the regulation of transcription.We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1 (show HDAC1 Antibodies)).
the association of hMI-ER1 with Sp1 (show PSG1 Antibodies) represents a novel mechanism for the negative regulation of Sp1 (show PSG1 Antibodies) target promoters
Loss of nuclear MI-ER1 alpha might contribute to the development of invasive breast carcinoma
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). In human, this gene functions as a growth-factor-induced immediate early gene that encodes a transcriptional regulator. Depending on the cellular context, this gene can function as both an activator and repressor of gene transcription. Alternative splicing results in multiple isoforms\; some of which contain a nuclear localization signal.
early response 1
, mesoderm induction early response protein 1
, Mesoderm induction early response protein 1
, mesoderm induction early response 1 homolog a
, mesoderm induction early response 1 homolog