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Dihydrofolate Reductase Products

(Dihydrofolate Reductase (DHFR))
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq, Jul 2008].

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Featured Dihydrofolate Reductase Categories

Dihydrofolate Reductase Antibodies

High quality antibodies with extensive validation data.

Dihydrofolate Reductase ELISA Kits

Reliable ELISA kits for a wide range of species.

Dihydrofolate Reductase Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Dihydrofolate Reductase Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, ELISA, WB
Validations
  • (6)
  • (6)
Cat. No. ABIN560600
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog, Human, Monkey
Application IF, IHC, IHC (p), WB
Validations
  • (7)
Cat. No. ABIN1497822
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (1)
  • (5)
Cat. No. ABIN3043286
Quantity 100 μg
Datasheet Datasheet

Recommended Dihydrofolate Reductase ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966361
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966362
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966363
Quantity 96 tests
Datasheet Datasheet

Recommended Dihydrofolate Reductase Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3079081
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3132337
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709401
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Dihydrofolate Reductase products

Jabs, Oelze, Mikhed, Stamm, Kröller-Schön, Welschof, Jansen, Hausding, Kopp, Steven, Schulz, Stasch, Münzel, Daiber: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).

Kossmann, Hu, Steven, Schönfelder, Fraccarollo, Mikhed, Brähler, Knorr, Brandt, Karbach, Becker, Oelze, Bauersachs, Widder, Münzel, Daiber, Wenzel: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).

Oelze, Kröller-Schön, Welschof, Jansen, Hausding, Mikhed, Stamm, Mader, Zinßius, Agdauletova, Gottschlich, Steven, Schulz, Bottari, Mayoux, Münzel, Daiber et al.: "The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and ..." in: PLoS ONE, Vol. 9, Issue 11, pp. e112394, (2014) (PubMed).

Tian, Zhang, Ge, Xiao, Lu, Fu, Liu, Sun: "MicroRNA-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma." in: Medical oncology (Northwood, London, England), Vol. 31, Issue 1, pp. 785, (2013) (PubMed).

Vodenicharov, Laterreur, Wellinger: "Telomere capping in non-dividing yeast cells requires Yku and Rap1." in: The EMBO journal, Vol. 29, Issue 17, pp. 3007-19, (2010) (PubMed).

Yoon, Choi, Kim, Shin, Zhang, Kang: "Influence of reduced folate carrier and dihydrofolate reductase genes on methotrexate-induced cytotoxicity." in: Cancer research and treatment : official journal of Korean Cancer Association, Vol. 42, Issue 3, pp. 163-71, (2010) (PubMed).

Ionova, Vásquez-Vivar, Whitsett, Herrnreiter, Medhora, Cooley, Pieper: "Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes." in: American journal of physiology. Heart and circulatory physiology, Vol. 295, Issue 5, pp. H2178-87, (2008) (PubMed).

Eymin, Gazzeri, Brambilla, Brambilla: "Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma." in: Oncogene, Vol. 20, Issue 14, pp. 1678-87, (2001) (PubMed).

de Wind, Dekker, Claij, Jansen, van Klink, Radman, Riggins, van der Valk, vant Wout, te Riele: "HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions." in: Nature genetics, Vol. 23, Issue 3, pp. 359-62, (1999) (PubMed).

Tang, Pao, Zhang: "Repair of benzo(a)pyrene diol epoxide- and UV-induced DNA damage in dihydrofolate reductase and adenine phosphoribosyltransferase genes of CHO cells." in: The Journal of biological chemistry, Vol. 269, Issue 17, pp. 12749-54, (1994) (PubMed).

Synonyms and alternative names related to Dihydrofolate Reductase

confers resistance to sulfonamides (dhfr), dihydrofolate reductase (DHFR), dihydrofolate reductase (dhfR), dihydrofolate reductase (dhfr), dihydrofolate reductase (folA), dihydrofolate reductase (dfrA), dihydrofolate reductase (LOC707382), dihydrofolate reductase DhfR (dhfR), dihydrofolate reductase (CNJ01940), dihydrofolate reductase (DDB_G0286755), Dihydrofolate reductase (Dhfr), Dihydrofolate reductase (Mesil_0096), Dihydrofolate reductase (Arch_0408), dihydrofolate reductase (Fbal_3367), dihydrofolate reductase (Ilyop_0482), dihydrofolate reductase (Lbys_2007), dihydrofolate reductase (Riean_0733), Dihydrofolate reductase (Mrub_1855), Dihydrofolate reductase (Poras_0766), dihydrofolate reductase (Halhy_3552), dihydrofolate reductase (Mesop_3614), dihydrofolate reductase (LOC609048), dihydrofolate reductase (Dhfr), 8430436I03Rik, AA607882, AI662710, AW555094, cb595, CG14887, DDBDRAFT_0187132, DDBDRAFT_0230113, DDB_0187132, DDB_0230113, DHFR, dhfr, Dhfr1, DHFRP1, Dmel\\CG14887, DYR, ECK0049, F10_orf160, JW0047, tmrA, zgc:86637

Protein level used designations for Dihydrofolate Reductase

  • dihydrofolate reductase
  • dihydrofolate reductase DhfR
  • CG14887-PA
  • CG14887-PB
  • Dhfr-PA
  • Dhfr-PB
  • Dihydrofolate reductase
  • Dihydrofolate reductase 1 (active)
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