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DIO1 Products

(Deiodinase, Iodothyronine, Type I (DIO1))
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008].

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Featured DIO1 Categories

DIO1 Antibodies

High quality antibodies with extensive validation data.

DIO1 ELISA Kits

Reliable ELISA kits for a wide range of species.

DIO1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DIO1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7236774
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ICC, IF, IHC, WB
Validations
  • (2)
Cat. No. ABIN6261300
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN2158551
Quantity 400 μL
Datasheet Datasheet

Recommended DIO1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955326
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966305
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966306
Quantity 96 tests
Datasheet Datasheet

Recommended DIO1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3122885
Quantity 0.25 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3081920
Quantity 0.5 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351604
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our DIO1 products

Wang, Dai, Zhang, Liu, Huang: "Jinlida Granules Improve Dysfunction of Hypothalamic-Pituitary-Thyroid Axis in Diabetic Rats Induced by STZ." in: BioMed research international, Vol. 2018, pp. 4764030, (2019) (PubMed).

Pałkowska-Goździk, Bigos, Rosołowska-Huszcz: "Type of sweet flavour carrier affects thyroid axis activity in male rats." in: European journal of nutrition, (2017) (PubMed).

Synonyms and alternative names related to DIO1

iodothyronine deiodinase 1 (DIO1), type I iodothyronine deiodinase-like (LOC100231867), deiodinase, iodothyronine, type I (Dio1), deiodinase, iodothyronine type 1 L homeolog (dio1.L), iodothyronine deiodinase 1 (dio1), 5DI, cb685, D1, Deio1, DIOI, ITDI1, TXDI1, zgc:92323

Protein level used designations for DIO1

  • DIOI
  • thyroxine deiodinase type I (selenoprotein)
  • type 1 DI
  • type I iodothyronine deiodinase
  • type-I 5'-deiodinase
  • thyroxine deiodinase, type I
  • 5DI
  • thyroxine deiodinase type 1
  • Type 1 DI
  • Type-I 5'-deiodinase
  • deiodinase, iodothyronine, type I
  • type 1 deiodinase
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