Browse our MLH1 Proteins (MLH1)

Full name:: MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) Proteins (MLH1)

On www.antibodies-online.com are 7 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Proteins from 0 different suppliers available. A total of 202 MLH1 products are currently listed.

Synonyms:: 1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301

list all proteins	Gene Name	GeneID	UniProt
Mouse MLH1	MLH1	17350	Q9JK91
Human MLH1	MLH1	4292	P40692
Rat MLH1	MLH1	81685	P97679
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Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

Results suggest that Xenopus MBD4 (show MBD4 Proteins)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.
In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.
Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Proteins) genes, mlh1, msh2 (show MSH2 Proteins), and msh6 (show MSH6 Proteins), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected
radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.
these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT (show HTT Proteins) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains
Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.
nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
suggesting a role for the ATPase activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 Proteins) partner PMS2 (show PMS2 Proteins)
Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Proteins) and brain tumour multicellular spheroids.
MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.
Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 Proteins) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

Data suggest that the concurrent mutations of the adenomatous polyposis coli protein (APC (show APC Proteins)) and mutL protein homolog 1 (MLH1) genes probably underline the familial adenomatous polyposis (FAP) in the pedigree.
Among 13 gastric tumors showing no hMLH1 or hMSH2 (show MSH2 Proteins) expression, 8 MSI (show MSI1 Proteins)-H (high) and 5 MSI (show MSI1 Proteins)-L (low) were identified.
Results show that folate concentrations >45.3 nmol/L increased the risk of methylation in specific CpG sites of MLH1.
In contrast to colorectal carcinoma, sporadic MLH1 deficiency is not seen in small bowel adenocarcinoma
MLH1 methylation is associated with colorectal cancer.
We found no correlation between the DLEC1, TUSC4 (show NPRL2 Proteins) and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 (show NPRL2 Proteins) and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population.
The results of this meta-analysis show a significant association between hMLH1 hypermethylation and colorectal cancer risk.
study to estimate frequency of point mutations and chromosomal rearrangements in 3 mismatch repair (MMR (show MRC1 Proteins)) genes MLH1, MSH2 (show MSH2 Proteins), and MSH6 (show MSH6 Proteins) among unselected patients with ovarian cancer; estimate that approximately 0.6% of unselected ovarian cancer patients have mutations in the MMR (show MRC1 Proteins) genes
CpG island methylator phenotype (CIMP)+/MLH1-unmethylated (MLH1-U) tumors exhibit aggressive features and are associated with poor clinical outcomes.
Analysis of expression Quantitative Trait Loci (eQTLs) provides modest support for altered regulation of MLH1 and LRRFIP2 (show LRRFIP2 Proteins), raising the possibility that the modifier affects regulation of both genes.

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Protein Profile

Protein Summary

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

mutL homolog 1 (MLH1)
CG11482 gene product from transcript CG11482-RB (Mlh1)
mutL homolog 1 S homeolog (mlh1.S)
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1)
DNA mismatch repair protein Mlh1 (LOC588545)
mutL homolog 1 (mlh1)
mutL homolog 1 (Mlh1)

1110035C23Rik protein
AI317206 protein
AI325952 protein
AI561766 protein
CG11482 protein
COCA2 protein
Dmel\\CG11482 protein
dmlh-1 protein
dmlh1 protein
FCC2 protein
hMLH1 protein
HNPCC protein
HNPCC2 protein
LOC100232198 protein
MLH1 protein
zgc:66301 protein

Protein level used designations for MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

GENE ID	SPECIES
420729	Gallus gallus
35796	Drosophila melanogaster
100036779	Xenopus laevis
100337665	Sus scrofa
393632	Danio rerio
588545	Strongylocentrotus purpuratus
747104	Pan troglodytes
100011682	Monodelphis domestica
100050351	Equus caballus
100232198	Taeniopygia guttata
100406787	Callithrix jacchus
100436876	Pongo abelii
100476536	Ailuropoda melanoleuca
100555611	Anolis carolinensis
100593390	Nomascus leucogenys
17350	Mus musculus
4292	Homo sapiens
81685	Rattus norvegicus
477019	Canis lupus familiaris
533652	Bos taurus

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