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|Antigen||Adenylate Cyclase 5 (ADCY5) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ADCY5 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Product Details anti-ADCY5 AntibodyTarget Details ADCY5 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of A Cyclase V/VI protein. (region surrounding Phe1052)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Also reacts to: ADCY6
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Plasmids, Primers & others|
Target Details ADCY5Product Details anti-ADCY5 Antibody Application Details Handling Images back to top
|Alternative Name||Adenylate Cyclase Type 5 (ADCY5 Antibody Abstract)|
|Background||A cyclase V, also known as ADCY5, is a 1,261 amino acid Adenylyl cyclase that localizes to cellular membranes and contains two guanylate cyclase domains. Similar to other A cyclase proteins, A cyclase V uses magnesium as a cofactor to catalyze the conversion of ATP to cAMP. A cyclase VI, also known as ADCY6 (adenylate cyclase type 6), is a 1,168 amino acid A cyclase that localizes to the membrane and contains two guanylate cyclase domains. Using magnesium as a cofactor, A cyclase VI functions as a calcium-inhibitable A cyclase that catalyzes the conversion of ATP to 3',5'-cyclic AMP and diphosphate and plays a role in a variety of events throughout the body. Multiple isoforms of A cyclase VI exist due to alternative splicing events.Synonyms: ADCY5, ATP pyrophosphate-lyase 5, Adenylate cyclase type V, Adenylyl cyclase 5|
|Molecular Weight||approx. 138 kDa|
|Pathways||EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma|
Application DetailsProduct Details anti-ADCY5 Antibody Target Details ADCY5 Handling Images back to top
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 -1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-ADCY5 Antibody Target Details ADCY5 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-ADCY5 Antibody Target Details ADCY5 Application Details Handling back to top