Browse our anti-NCK2 (NCK2) Antibodies

Human NCK Adaptor Protein 2 (NCK2) interaction partners

1. This study provides evidence of a possible role of NCK2 as biomarker of ovarian cancer progression.

2. There was no difference in the Nck2 mRNA expression between the SLE patients and the healthy subjects.

3. Nck1 and Nck2 Interact with WTIP. Nck1/2 integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP.

4. Data suggest that PINCH1 and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR function and downstream signaling in a cellular model of human squamous cell carcinoma.

5. Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP).

6. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.

7. NCK2 is involved in the susceptibility to opiates addiction.

8. The hNck2 SH3 domain also exhibited pH dependent monomer-dimer transition.

9. Data show that both HK2 and NCK2 are expressed in the retinal ganglion cell layer.

10. Nck2 effectively influences human melanoma phenotype progression.

11. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.

12. Nck2 is an adaptor protein composed of 3N-SH3 domains followed by a unique Cterminal SH2 domain. It interacts with PINCH in integrin signal transduction, cell migratio and survival. Review.

13. biophysical analysis of Nck2 SH3 domain

14. Nck-2 interacts with focal adhesion kinase and modulates cell motility. Using a mutational strategy, the formation of the Nck-2-FAK complex is mediated by interactions involving multiple SH2 and SH3 domains of Nck-2.

15. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.

16. analysis of binding between the Tyr-phosphorylated human ephrinB2 and Nck2 SH2 domain

17. Molecular model of the first SRC homology 3 domain of Nck2.

18. Nck1 (Nckalpha) and Nck2 (Nckbeta and Grb4): binding specificities of both SH2 domains are essentially indistinguishable

19. determined the NMR structures and dynamic properties of the hNck2 SH3 domains and to define their ligand binding preferences with nine proline-rich peptides derived from Wire, CAP-1, CAP-2, Prk, Wrch1, Wrch2, and Nogo

20. Data show that Nck (isoforms 1 and 2) as a component of the CReP/PP1c holophosphatase complex contributes to maintain eIF2alpha in a hypophosphorylated state, and modulates translation and eIF2alpha signaling in response to ER stress.

Mouse (Murine) NCK Adaptor Protein 2 (NCK2) interaction partners

1. Authors propose that Nck2 should be further investigated as a regulator of the reliance of white adipose tissue on hyperplasia versus hypertrophy during adipose tissue expansion, and hence, as a potential novel molecular target in obesity.

2. Findings reveal that Nck2 is a novel regulator of adiposity and suggest that Nck2 is important in limiting WAT expansion and dysfunction in mice and humans.

3. Inactivation of NCK2 (and NCK1) inhibits endothelial cell polarity.

4. These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass.

5. we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord

6. Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.

7. Data show that only Nck2 is required for the Slit1-induced changes in cortical neuron morphology in vitro.

8. These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.

9. The Cas utilizes Nck2 to activate Cdc42 and induce cell polarization in response to wound healing.

10. Nck1 and Nck2 have roles in cell movement and cytoskeletal organization

11. Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons

12. nephrin selectively binds the Src homology 2 (SH2)/SH3 domain-containing Nck adaptor proteins, which in turn control the podocyte cytoskeleton in vivo

13. Nck adaptors play an essential role in linking the activated platelet-derived growth factor B receptor with actin dynamics through a pathway that involves p130(Cas)

14. Data show that Nck (isoforms 1 and 2) as a component of the CReP/PP1c holophosphatase complex contributes to maintain eIF2alpha in a hypophosphorylated state, and modulates translation and eIF2alpha signaling in response to ER stress.

15. the Nck adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor

16. Grb4 is a key mediator for transducing ephrin B3 reverse signals involved in axon pruning in cultured hippocampal granule cell neurons.

17. independent roles and mechanisms of action of Nckalpha and Nckbeta in dermal fibroblast migration, which is critical for wound healing.

18. Transduces B-ephrin reverse signals.