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|Antigen||Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This STAM antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-STAM AntibodyTarget Details STAM Application Details Handling Images
|Specificity||This antibody is specific to STAM (C-term).|
|Purification||Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human STAM.|
|Plasmids, Primers & others|
Target Details STAMProduct Details anti-STAM Antibody Application Details Handling Images back to top
|Alternative Name||STAM1 (STAM Antibody Abstract)|
|Background||Stimulation of cells with cytokines initiates a signal transduction cascade involving cytokine receptors, Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). STAM for 'signal-transducing adaptor molecule, induced after stimulation of cells with cytokine IL2, is a component of signal transduction downstream of JAK3.1 Human STAM cDNA cloned from a T-cell cDNA library encodes a 540-amino acid protein precipitated by anti-phosphotyrosine. Northern blot analysis indicates that STAM is expressed as a 2.9-kb message in a wide variety of tissue and cell types. The STAM sequence contains a Src-homology 3 (SH3) domain and an immunoreceptor tyrosine-based activation motif (ITAM). It has been suggested that STAM acts as an adaptor molecule in signal transduction pathways from cytokine receptors.Synonyms: HSE1 homolog, STAM, STAM-1, Signal transducing adapter molecule 1|
|Molecular Weight||59179 Da|
|Gene ID||8027, 9606|
|Pathways||EGFR Signaling Pathway, EGFR Downregulation|
Application DetailsProduct Details anti-STAM Antibody Target Details STAM Handling Images back to top
ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAM Antibody Target Details STAM Application Details Images back to top
|Buffer||PBS with 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ImagesProduct Details anti-STAM Antibody Target Details STAM Application Details Handling back to top