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Human Polyclonal ATG10 Primary Antibody for ICC, IF - ABIN4282063
Song, Mitter, Qi, Beli, Rao, Ding, Ip, Gu, Akin, Dunn, Bowes Rickman, Lewin, Grant, Boulton: Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. in PLoS ONE 2017
ATG10 rs1864182 gene polymorphism was associated with the decreased risk of coal workers' pneumoconiosis in a Chinese population.
Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10, Wnt5a (show WNT5A Antibodies), alpha1 integrin (show ITGA1 Antibodies), and matrix metalloproteinase-3 (show MMP3 Antibodies) in GS/BMP-4 (show BMP4 Antibodies)-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.
Expression of ATG10 negatively regulated by PTBP1 (show PTBP1 Antibodies) and is associated with metastasis of colorectal cancer cells.
Findings suggest that eQTL/meQTL variations of ATG10 could influence lung cancer survival through regulating ATG10 expression.
3 novel miRNAs, MIR4458, MIR4667-5p, and MIR4668-5p, regulate autophagy-mediated elimination of B. pseudomallei by targeting ATG10
results suggest that genetic variants in ATG10 may implicate with breast cancer susceptibility in Chinese population. Further large and functional studies are needed to confirm our findings
Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis indicating that ATG10 may be a potential prognostic maker in colorectal cancer.
These results indicate that ATG10 is essential for ATG12 conjugation and that the ATG12-ATG5 conjugate is necessary to form autophagic vesicles and for the timely progression of senescence and programmed cell death in plants.
APG10 has a role in mediating the conjugation of APG12 with APG5 (show ATG5 Antibodies)
The isolated mouse APG10 gene product interacts with mammalian Apg12p dependent on mammalian Apg7p (E1-like enzyme), and facilitates Apg12p conjugation.
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A\; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003
ATG10 autophagy related 10 homolog
, autophagy-related protein 10
, ubiquitin-like-conjugating enzyme ATG10
, autophagy related 10 homolog
, autophagy-related 10
, AuTophaGy (yeast Atg homolog) family member (atg-10)
, ATG10 autophagy related 10 homolog (S. cerevisiae)
, APG10 autophagy 10-like
, potential E2-like Atg12p-Atg5p conjugation enzyme Atg10