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Human ERN1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004877
Trentmann: ERN1, a novel ethylene-regulated nuclear protein of Arabidopsis. in Plant molecular biology 2000
Show all 5 Pubmed References
Human ERN1 Protein expressed in HEK-293 Cells - ABIN2720502
Lee, Wang, Reyes, Armstrong, Kulikowicz, Santos, Lee, Koehler, Martin: Hypothermia and Rewarming Activate a Macroglial Unfolded Protein Response Independent of Hypoxic-Ischemic Brain Injury in Neonatal Piglets. in Developmental neuroscience 2016
this study highlights an important role for Nck1 (show NCK1 Proteins) in fine-tuning IRE1alpha expression and signaling that regulate PTP1B (show PTPN1 Proteins) expression and subsequent activation of the PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) pathway in HepG2 cells.
IRE1alpha-XBP1 (show XBP1 Proteins) pathway regulates Mel (show RAB8A Proteins)-RMu cell proliferation and progression by activating IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling.
The authors propose that the Sec61 (show SEC61A1 Proteins)-IRE1alpha complex defines the extent of IRE1alpha activity and may determine cell fate decisions during endoplasmic reticulum stress conditions.
ERN1 and ALPK1 (show ALPK1 Proteins) inhibit differentiation of bi-potential tumor-initiating cells in human triple negative breast cancer.
IRE1 deficiency fully restored the learning and memory capacity of AD mice, associated with improved synaptic function and improved long-term potentiation (LTP (show SCP2 Proteins)). At the molecular level, IRE1 deletion reduced the expression of amyloid precursor protein (APP (show APP Proteins)) in cortical and hippocampal areas of AD mice.
The biologic processes altered by aberrant IRE1alpha-XBP1 (show XBP1 Proteins) signaling in these innate immune cells.
Inhibition of IRE1 modifies the hypoxic regulation of GADD34 (show PPP1R15A Proteins) family gene expression in cultured glioma cells.
Changes in the expression level of nuclear genes encoding mitochondrial proteins possibly reflect metabolic reprogramming of mitochondria by hypoxia and IRE1-mediated endoplasmic reticulum stress signaling and correlate with suppression of glioma cell proliferation under inhibition of the IRE1 enzyme function.
The inhibition of IRE1 changes sensitivity of the expression of down-stream genes to glutamine deprivation in cultured glial tumor cells.
The present study demonstrated that the inhibition of IRE1 in glioma cells affected the hypoxic regulation of the expression of down-stream genes in various directions, though hypoxic conditions did not abolish the effect of IRE1 inhibition on the expression of respective genes.
IRE1alpha has a critical role in colonic tumorigenesis and IRE1alpha targeting might be a strategy for treatment of colon cancers.
Study provided the first link between energy homeostasis, lipid metabolism and pro-opiomelanocortin (POMC (show POMC Proteins)) neuronal IRE1alpha function. The effects of POMC (show POMC Proteins) IRE1alpha knockout were mediated via increased thermogenesis, possibly caused by the increased alpha-MSH production in the hypothalamus. These results demonstrate that IRE1alpha in POMC (show POMC Proteins) neurons plays a critical role in the regulation of obesity and obesity-related m...
Data show that LPS (show TLR4 Proteins) induces endoplasmic reticulum (ER) stress and P300 (show NOTCH1 Proteins) activity via the XBP1 (show XBP1 Proteins)/IRE1 pathway.
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
Data suggest that activation of GRP78 (show HSPA5 Proteins)/Ire1/Xbp1 (show XBP1 Proteins) pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.
defective autophagy in intestinal epithelial cells (IECs) may predispose to Crohn's disease ileitis via impaired clearance of IRE1alpha aggregates during ER stress at this site.
The findings indicate that IRE1-XBP1 (show XBP1 Proteins) downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth.
the ABL (show ABL1 Proteins) family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
ER to nucleus signalling 1
, endoplasmic reticulum-to-nucleus signaling 1
, inositol-requiring 1
, inositol-requiring enzyme 1
, inositol-requiring protein 1
, protein kinase/endoribonuclease
, serine/threonine-protein kinase/endoribonuclease IRE1
, endoplasmic reticulum to nucleus signalling 1
, inositol-requiring 1 alpha
, endoplasmic reticulum (ER) to nucleus signalling 1
, endoplasmic reticulum-to-nucleus signaling 2
, inositol-requiring 1 (Yeast homologue)
, inositol-requiring 1 beta
, inositol-requiring protein 2
, serine/threonine-protein kinase/endoribonuclease IRE2
, endoplasmic reticulum to nucleus signaling 1