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Human Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

1. IRE1alpha is expressed at lower levels in higher-grade gliomas, suggesting greater antitumor efficacy of the oncolytic virus M1. Taken together, these findings illustrate a defensive mechanism of glioma cells against the oncolytic virus M1 and identify possible approaches to enhance the oncolytic viral protein accumulation and the subsequent lysis of tumor cells.

2. Systematic mutation of the AREs (ARE1-3) in the LDLR 3'UTR and expression of each mutant coupled to a luciferase reporter in Huh7 cells demonstrated that ARE1 is required for rapid LDLR mRNA decay and 5-AzaC-induced mRNA stabilization via the IRE1alpha-EGFR-ERK1/2 signaling cascade.

3. Pharmacologic modulation of IRE1 counteracts metaflammation and alleviates atherosclerosis.

4. Present study demonstrates that fine-tuning of the expression of proliferation related transcription factor genes depends upon glucose and glutamine (show GFPT1 Proteins) deprivation in IRE1-dependent manner and possibly contributes to slower tumor growth after inhibition of IRE1.

5. The activation of IRE1alpha by the hepatitis C virus protein NS4B in XBP1 (show XBP1 Proteins)-proficient cells conferred apoptosis resistance and promoted viral replication.

6. this study highlights an important role for Nck1 (show NCK1 Proteins) in fine-tuning IRE1alpha expression and signaling that regulate PTP1B (show PTPN1 Proteins) expression and subsequent activation of the PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) pathway in HepG2 cells.

7. IRE1alpha-XBP1 (show XBP1 Proteins) pathway regulates Mel (show RAB8A Proteins)-RMu cell proliferation and progression by activating IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling.

8. The authors propose that the Sec61 (show SEC61A1 Proteins)-IRE1alpha complex defines the extent of IRE1alpha activity and may determine cell fate decisions during endoplasmic reticulum stress conditions.

9. ERN1 and ALPK1 (show ALPK1 Proteins) inhibit differentiation of bi-potential tumor-initiating cells in human triple negative breast cancer.

10. IRE1 deficiency fully restored the learning and memory capacity of AD mice, associated with improved synaptic function and improved long-term potentiation (LTP (show SCP2 Proteins)). At the molecular level, IRE1 deletion reduced the expression of amyloid precursor protein (APP (show APP Proteins)) in cortical and hippocampal areas of AD mice.

Mouse (Murine) Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

1. IRE1alpha has a critical role in colonic tumorigenesis and IRE1alpha targeting might be a strategy for treatment of colon cancers.

2. Study provided the first link between energy homeostasis, lipid metabolism and pro-opiomelanocortin (POMC (show POMC Proteins)) neuronal IRE1alpha function. The effects of POMC (show POMC Proteins) IRE1alpha knockout were mediated via increased thermogenesis, possibly caused by the increased alpha-MSH production in the hypothalamus. These results demonstrate that IRE1alpha in POMC (show POMC Proteins) neurons plays a critical role in the regulation of obesity and obesity-related m...

3. cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.

4. Data suggest that activation of GRP78 (show HSPA5 Proteins)/Ire1/Xbp1 (show XBP1 Proteins) pathway of ER stress-unfolded protein response is involved in mouse decidualization.

5. Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.

6. defective autophagy in intestinal epithelial cells (IECs) may predispose to Crohn's disease ileitis via impaired clearance of IRE1alpha aggregates during ER stress at this site.

7. The findings indicate that IRE1-XBP1 (show XBP1 Proteins) downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth.

8. the ABL (show ABL1 Proteins) family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.

9. We reveal distinct binding affinities between the binary and ternary complexes thus formed, that suggest a preference for the PERK (show EIF2AK3 Proteins) signaling branch under stress, and a predilection for the GRP78 (show HSPA5 Proteins)-UPR sensor complex formation upon stressor removal. These results imply a gated UPR mechanism that tunes the overall cellular behavior to the accumulation of unfolded proteins.

10. Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs.