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anti-Human HDGF Antibodies:
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miR139 was downregulated in epithelial ovarian cancer, and acted as a tumor suppressor by directly targeting HDGF.
high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of non-small cell lung cancer.
Data suggested that HDGF knockdown inhibits cellular migration and invasion in vitro of prostate cancer via modulating epithelial-mesenchymal transition signaling pathway, as well as MMP2 (show MMP2 Antibodies) and MMP9 (show MMP9 Antibodies) signaling pathway. These results supported that HDGF is a relevant protein in the progression of prostate cancer and may serve as a potentially therapeutic target for prostate cancer as well as its downstream targets.
HDGF is overexpressed in both androgen-sensitive and androgen-insensitive cell lines. Forced overexpression enhanced cell viability but knockdown reduced proliferation of benign prostate cells.Ectopic HDGF overexpression of HDGF in up-regulated cyclin E (show CCNE1 Antibodies) and BCL-2 (show BCL2 Antibodies), but down-regulated BAX (show BAX Antibodies). Treatment with a HDGF monoclonal antibody and vitamin K2 reduced proliferation and inhibited NF-kB expression in a tumor cell line.
functional diversity of HDGF isoforms
our findings first indicate that the interaction of HDGF and beta-catenin (show CTNNB1 Antibodies) may play a crucial role in tumorigenesis of synovial sarcoma.
HDGF was overexpressed in hepatocellular carcinoma patients and cells.
miRNA497 directly targets hepatomaderived growth factor (HDGF) in prostate cancer cells.
describe two previously unknown HDGF isoforms, HDGF-B and HDGF-C, generated via alternative splicing with structurally unrelated N-terminal regions of their hath region
study uncovers a novel function of HDGF as a messenger of cellular condition (alarmin) which in-turn modulates cellular function-aspects that could be used as a biomarker for ovarian cancer.
HDGF is synthesized similarly by the endometrium and embryo, and it may exert embryotropic effects by autocrine and/or paracrine mechanisms.
involvement of HDGF during the initiation phase of the apoptotic process downstream from an initiator Caspase (show CASP3 Antibodies) and regulation of this protein by phosphorylation in the nucleus
liver cancer cell-derived HDGF can induce Foxp3 (show FOXP3 Antibodies)(+) T cells; the latter has immune suppressor functions on CD8 (show CD8A Antibodies)(+) T cell activities
Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma.
HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene (show RAB1A Antibodies) addiction of tumor tissue.
HDGF exploits the innate properties of both cell surface heparan sulfates and membrane receptor via the HATH domain to affect related cell signalling processes
HDGF plays a pro-fibrogenic role during liver fibrosis in mice through activation of TGF-beta (show TGFB1 Antibodies) pathway.
Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus
Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development.
Increased HDGF expression is correlated with disease progression of hepatocellular carcinoma and represent a specific prognostic factor in patient with liver cancer.
we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action.
HDGF is a novel type of neurotrophic factor (show NTF3 Antibodies) harbored in the nucleus and it functions in an autocrine manner.
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
, high mobility group protein 1-like 2
, hepatoma-derived growth factor (high-mobility group protein 1-like)
, hepatoma-derived growth factor