Browse our anti-HDGF (HDGF) Antibodies

Human Hepatoma-Derived Growth Factor (HDGF) interaction partners

1. miR139 was downregulated in epithelial ovarian cancer, and acted as a tumor suppressor by directly targeting HDGF.

2. high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of non-small cell lung cancer.

3. Data suggested that HDGF knockdown inhibits cellular migration and invasion in vitro of prostate cancer via modulating epithelial-mesenchymal transition signaling pathway, as well as MMP2 and MMP9 signaling pathway. These results supported that HDGF is a relevant protein in the progression of prostate cancer and may serve as a potentially therapeutic target for prostate cancer as well as its downstream targets.

4. HDGF is overexpressed in both androgen-sensitive and androgen-insensitive cell lines. Forced overexpression enhanced cell viability but knockdown reduced proliferation of benign prostate cells.Ectopic HDGF overexpression of HDGF in up-regulated cyclin E and BCL-2, but down-regulated BAX. Treatment with a HDGF monoclonal antibody and vitamin K2 reduced proliferation and inhibited NF-kB expression in a tumor cell line.

5. functional diversity of HDGF isoforms

6. our findings first indicate that the interaction of HDGF and beta-catenin may play a crucial role in tumorigenesis of synovial sarcoma.

7. HDGF was overexpressed in hepatocellular carcinoma patients and cells.

8. miRNA497 directly targets hepatomaderived growth factor (HDGF) in prostate cancer cells.

9. describe two previously unknown HDGF isoforms, HDGF-B and HDGF-C, generated via alternative splicing with structurally unrelated N-terminal regions of their hath region

10. study uncovers a novel function of HDGF as a messenger of cellular condition (alarmin) which in-turn modulates cellular function-aspects that could be used as a biomarker for ovarian cancer.

11. HDGF and beta-catenin interact as a positive feedback loop, which plays an important role in carcinogenesis and progression of colorectal carcinoma.

12. HDGF is important in promoting malignant biological behaviors, including proliferation, migration and invasion of hilar cholangiocarcinoma cells.

13. Hepatoma-derived growth factor overexpression is involved in liver carcinogenesis.

14. Meta-analysis results provide evidence that HDGF may be a new indicator of poor cancer prognosis.

15. HDGF contains conserved N-terminal HATH domains with a characteristic structural motif, namely the PWWP motif. This study defines the role of the first residue of the PWWP motif in modulating HATH domain stability and oligomer formation in binding.

16. HDGF overexpression is common in early-stage cervical adenocarcinoma.

17. The expression level of hepatoma-derived growth factor (HDGF) significantly decreased in response to the virus-associated RNAs under replication-deficient condition.

18. HDGF can promote IHCC cells progression, including proliferation, invasion, and angiogenesis

19. Results suggest that HDGF downregulation significantly suppresses glioma cell proliferation, migration, invasion in vitro and tumorigenesis in vivo is probably involved in the activation of both the PI3K/Akt and the TGF-beta signaling pathways

20. These data suggested that irradiated fibroblasts promoted invasion, growth, EMT and HDGF expression of ESCC.

Cow (Bovine) Hepatoma-Derived Growth Factor (HDGF) interaction partners

1. HDGF is synthesized similarly by the endometrium and embryo, and it may exert embryotropic effects by autocrine and/or paracrine mechanisms.

2. involvement of HDGF during the initiation phase of the apoptotic process downstream from an initiator Caspase and regulation of this protein by phosphorylation in the nucleus

Mouse (Murine) Hepatoma-Derived Growth Factor (HDGF) interaction partners

1. liver cancer cell-derived HDGF can induce Foxp3(+) T cells; the latter has immune suppressor functions on CD8(+) T cell activities

2. Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma.

3. HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue.

4. HDGF exploits the innate properties of both cell surface heparan sulfates and membrane receptor via the HATH domain to affect related cell signalling processes

5. HDGF plays a pro-fibrogenic role during liver fibrosis in mice through activation of TGF-beta pathway.

6. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus

7. Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development.

8. Increased HDGF expression is correlated with disease progression of hepatocellular carcinoma and represent a specific prognostic factor in patient with liver cancer.

9. we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action.

10. HDGF is a novel type of neurotrophic factor harbored in the nucleus and it functions in an autocrine manner.

11. hepatoma-derived growth factor has roles in development and intestinal neoplasms

12. HDGF is a novel trophic factor for motor neurons and it might play a protective role against motor neuron degeneration.

13. The lack of obvious biochemical and morphological phenotypes in HDGF-deficient mice demonstrates that in vivo HDGF is dispensable for normal development in mice.

14. HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP.