ErbB2/Her2 Proteins
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
| Catalog no. | Product | Reactivity | Host / Clonality | Application | Price & lead time |
|---|---|---|---|---|---|
| ErbB2/Her2 Protein (AA 23-652) (His tag,Biotin) | Human | HEK-293 Cells |
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$2,130.92
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| ErbB2/Her2 Protein (AA 23-652) (Fc Tag) | Human | HEK-293 Cells |
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$444.46
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| ErbB2/Her2 Protein (AA 23-652) (His tag,AVI tag,Biotin) | Human | HEK-293 Cells |
|
$2,049.08
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| ErbB2/Her2 Protein (AA 23-652) (His tag) | Human | Mammalian Cells |
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$535.66
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| ErbB2/Her2 Protein (A775_G776insYVMA) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (P780_Y781insGSP) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (V842I) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (V956R) (His tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (V777_G778insCG) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (AA 755-759 deleted) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (D769H) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (D769Y) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (C805S) (GST tag) | Human | Baculovirus infected Insect Cells |
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$413.23
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| ErbB2/Her2 Protein (E719G) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (E719K) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (G776V) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (L755S, L869R) (GST tag) | Human | Baculovirus infected Insect Cells |
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$413.23
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| ErbB2/Her2 Protein (R896C) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
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| ErbB2/Her2 Protein (L785F) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
View price
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| ErbB2/Her2 Protein (V777L) (GST tag) | Human | Baculovirus infected Insect Cells |
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$402.46
View price
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Protein
- SDS (SDS-PAGE: Validation image available)
- Bind (Binding Studies: Validation image available)
2 references - Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- >95 % as determined by reduced SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN2444140
$2,130.92
Plus shipping costs $50.00
200 μg
(More quantities available)
Shipping to:
United States
Delivery in 2 to 4 Business Days
Protein
- SDS (SDS-PAGE: Validation image available)
- Bind (Binding Studies: Validation image available)
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- >95 % as determined by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN2181216
$444.46
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 2 to 4 Business Days
Protein
- SDS (SDS-PAGE: Validation image available)
- ELISA (ELISA: Validation image available)
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- >90 % as determined by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN5954984
$2,049.08
Plus shipping costs $50.00
200 μg
(More quantities available)
Shipping to:
United States
Delivery in 5 to 6 Business Days
Protein
- WB (Western Blotting: Listed application)
- SDS (SDS-PAGE: Listed application)
- Imm (Immunogen: Listed application)
- ELISA (ELISA: Listed application)
- AcA (Activity Assay: Listed application)
- Origin
- Human
- Host
- Mammalian Cells
- Protein Type
- Recombinant
- Purity
- >90 % as determined by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN7678322
$535.66
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 12 to 15 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856289
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856291
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856285
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856286
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856290
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856269
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856272
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856273
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856270
$413.23
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
Catalog No. ABIN7856274
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
Catalog No. ABIN7856275
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856276
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856279
$413.23
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856282
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856281
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Protein
- KAA (Kinase Activity Assay: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Biological Activity
- Active
Catalog No. ABIN7856284
$402.46
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Latest Publications for our ErbB2/Her2 Proteins
: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." in: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
Aliases for ErbB2/Her2 Proteins
erb-b2 receptor tyrosine kinase 2 (ERBB2) Proteinserb-b2 receptor tyrosine kinase 2 (Erbb2) Proteins
erb-b2 receptor tyrosine kinase 2 (erbb2) Proteins
c-erbB2 Proteins
c-neu Proteins
CD340 Proteins
erb2 Proteins
Erbb-2 Proteins
HER-2 Proteins
HER-2/neu Proteins
HER2 Proteins
mKIAA3023 Proteins
MLN 19 Proteins
NEU Proteins
Neu Proteins
NGL Proteins
TKR1 Proteins
wu:fv70f10 Proteins
zgc:63601 Proteins
Did you look for something else?
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- ERAP2 Proteins
- ERAP1 Proteins
- ERAL1 Proteins
- ER Lipid Raft Associated 2 Proteins
- EPYC Proteins
- EPX Proteins
- EPT1 Proteins
- EPSTI1 Proteins
- Epstein-Barr Virus Nuclear Antigen-1 Proteins
- Epsin 2 Proteins
- Epsin 1 Proteins
- EPS8-Like 3 Proteins
- EPS8-Like 2 Proteins
- EPS8-Like 1 Proteins
- EPS8 Proteins
- EPS15 Proteins
- EPRS Proteins
- Eppin Proteins
- EPO Proteins
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