TNF Receptor Superfamily, Member 6 Products
(TNF Receptor Superfamily, Member 6 (FAS))
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011].
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Featured TNF Receptor Superfamily, Member 6 Categories
TNF Receptor Superfamily, Member 6 Antibodies
High quality antibodies with extensive validation data.
TNF Receptor Superfamily, Member 6 ELISA Kits
Reliable ELISA kits for a wide range of species.
TNF Receptor Superfamily, Member 6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TNF Receptor Superfamily, Member 6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, ICC
Validations
- (2)
- (5)
Cat. No.
ABIN969518
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
- (5)
Cat. No.
ABIN3020739
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC (fro), IHC (p)
Validations
- (19)
- (4)
Cat. No.
ABIN3044338
Quantity
100 μg
Datasheet
Datasheet
Recommended TNF Receptor Superfamily, Member 6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (6)
Cat. No.
ABIN6730941
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6955699
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955700
Quantity
96 tests
Datasheet
Datasheet
Recommended TNF Receptor Superfamily, Member 6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274589
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274590
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274587
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TNF Receptor Superfamily, Member 6 products
: "EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression." in: Scientific reports, Vol. 10, Issue 1, pp. 12274, (2020) (PubMed).: "Dietary methionine restriction reduces hepatic steatosis and oxidative stress in high-fat-fed mice by promoting H2S production." in: Food & function, Vol. 10, Issue 1, pp. 61-77, (2019) (PubMed).
: "Danshensu Decreases UVB-Induced Corneal Inflammation in an Experimental Mouse Model via Oral Administration." in: Current eye research, Vol. 43, Issue 1, pp. 27-34, (2018) (PubMed).
: "Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients." in: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, Vol. 51, Issue 4, pp. 465-472, (2018) (PubMed).
: "Artesunate enhances γδ T-cell-mediated antitumor activity through augmenting γδ T-cell function and reversing immune escape of HepG2 cells." in: Immunopharmacology and immunotoxicology, Vol. 40, Issue 2, pp. 107-116, (2018) (PubMed).
: "Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli." in: Respiratory research, Vol. 19, Issue 1, pp. 91, (2018) (PubMed).
: "Prior Puma Lentivirus Infection Modifies Early Immune Responses and Attenuates Feline Immunodeficiency Virus Infection in Cats." in: Viruses, Vol. 10, Issue 4, (2018) (PubMed).
: "SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary." in: International journal of molecular medicine, Vol. 41, Issue 6, pp. 3115-3126, (2018) (PubMed).
: "Zinc Oxide Nanoparticles Induced Oxidative DNA Damage, Inflammation and Apoptosis in Rat's Brain after Oral Exposure." in: Toxics, Vol. 6, Issue 2, (2018) (PubMed).
: "Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 (-/-) mouse model." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 64, (2017) (PubMed).
Synonyms and alternative names related to TNF Receptor Superfamily, Member 6
Fas cell surface death receptor (FAS), Fas (TNF receptor superfamily member 6) (Fas), Fas cell surface death receptor (Fas), Fas cell surface death receptor (fas), AI196731, ALPS1A, APO-1, APO1, APT1, CD95, FAS1, FASTM, lpr, TNFR6, TNFRSF6, Tnfrsf6Protein level used designations for TNF Receptor Superfamily, Member 6
- APO-1 cell surface antigen
- CD95 antigen
- Delta Fas/APO-1/CD95
- FAS 827dupA
- FASLG receptor
- Fas (TNF receptor superfamily, member 6)
- Fas AMA
- TNF receptor superfamily member 6
- apoptosis antigen 1
- apoptosis-mediating surface antigen FAS
- tumor necrosis factor receptor superfamily member 6
- tumor necrosis factor receptor superfamily, member 6
- Fas antigen
- Fas (TNF receptor superfamily member)
- apo-1 antigen
- lymphoproliferation
- Fas antigen (ATP1)
- Fas receptor
- Tumor necrosis factor receptor superfamily, member 6
- apoptosis (APO-1) antigen 1 ( FAS ), member 6
- Fas receptor CD95
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