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The deletion contained 17 protein coding genes including PROKR2 and BMP2 (show BMP2 Proteins), both of which are expressed during embryological development of the pituitary gland. PROKR2 mutations have been associated with hypopituitarism but a heterozygous deletion of this gene with hypopituitarism is a novel observation.
PROKR2 genetic mutation plays a role in the pathogenesis of pituitary stalk interruption syndrome.
a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL) (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
Data suggest that prokineticins (PROK1 (show Prok1 Proteins) and PROK2 (show PROK2 Proteins)) and prokineticin receptors (PROKR1 (show PROKR1 Proteins) and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]
PROKR2 may play a role in susceptibility of pituitary stalk interruption syndrome
PROKR2 expression in human fetal ovary remained unchanged throughout gestation.
EG-VEGF (show Prok1 Proteins), BV8 (show PROK2 Proteins), and PROKR2 gene expression is approximately five, four, and two times higher in cystic fibrosis (show S100A8 Proteins) lungs compared with controls.
PKR2 protomers form type II dimers involving TMs (show TYMS Proteins) 4 and 5, with a role for TM5 in modulation of PKR2 function.
Study corroborates the clinical relevance of the EG-VEGF (show Prok1 Proteins) system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF (show Prok1 Proteins) and PROKR variants.
PK2-induced PKR2 endocytosis is GRK2- and clathrin-dependent, but beta-arrestin-independent.
This study presents the first experimental evidence indicating a molecular interaction between anosmin 1 (show KAL1 Proteins) and PKR2. A truncated anosmin 1 (show KAL1 Proteins) protein comprising the first three domains of the protein interacts with the second extracellular loop of PKR2, involved in PK2 (show PROK2 Proteins) binding.
Data show that the prokineticins and their receptors PROK2 (show PROK2 Proteins), PKR1 (show PROKR1 Proteins) and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
Studies indicate PK2 (show PROK2 Proteins) signaling is required for the maintenance of normal female estrous cycles.
We sought to clarify the role of PROKR2 in hypothalamopituitary development through analysis of Prokr2(-/-) mice.
Prokr2 is specifically expressed in the XY gonads during sex determination and fetal sexual differentiation, and knockout mice display a variable degree of compromised vasculature in the fetal testes
The functional characteristics of coronary endothelial cells depend on the expression of PKR1 (show PROKR1 Proteins) and PKR2 levels and the divergent signaling pathways used by these receptors.
prokineticin 2 (show PROK2 Proteins) is expressed in neurons of the mouse suprachiasmatic nucleus
Phenotypic analysis indicated that not Pkr1 (show PROKR1 Proteins)(-/-)but Pkr2(-/-)mice exhibited hypoplasia of the olfactory bulb.
PKR2 expression was maintained over 10.5dpc with both trophoblastic and endothelial cell localisations in mice.
Important role for Prokr2 in olfactory bulb neurogenesis.
G-protein-coupled receptor for prokineticin
G protein-coupled receptor 73-like 1
, G protein-coupled receptor I5E
, G-protein coupled receptor 73-like 1
, G-protein coupled receptor I5E
, prokineticin receptor 2
, prokineticin receptor 2-like