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HIF-2a regulates non-canonical glutamine (show GFPT1 Proteins) metabolism via activation of PI3K (show PIK3CA Proteins)/mTORC2 (show CRTC2 Proteins) pathway and GOT1 expression in human pancreatic ductal adenocarcinoma.
ALT is a more suitable index than AST for developing a regression model.
High AST1 expression is associated with high mortality in hemodialysis patients.
GOT1 plays an important role in energy metabolism and ROS (show ROS1 Proteins) balance in chronic acidosis stress in pancreatic tumor cells.
Early abnormal liver enzyme levels of aspartate aminotransferase and alanine aminotransferase may increase the prevalence of human cytomegalovirus antigenemia after hematopoietic stem cell transplantation.
Elevated preoperative aspartate aminotransferase-to-platelet ratio index may be independently associated with poor overall survival and disease-free survival in hepatocellular carcinoma patients following curative resection
Elevated levels of ALT are Associated with Cardiovascular disease.
Elevated aspartate aminotransferase level was associated with hepatocellular carcinoma.
The serum hepcidin, ferritin, alanine transaminase, aspartate transaminase, gamma-glutamyltransferase and bilirubin were examined in two independent Chinese cohorts consisted of 3455 individuals.
Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT1 rises due to up-regulation of hepatic expression of GOT1 associated with greater gluconeogenesis and insulin (show INS Proteins) resistance.
GOT1 is a suitable candidate gene for the serum aspartate aminotransferase activity QTL on SSC14.
Data show that the purifies prephenate aminotransferase activity is housed by the prokaryotic-type plastidic aspartate aminotransferase (At2g22250).
aspartate aminotransferase and glutamine synthetase (show GLUL Proteins) have roles in glucocorticoid activation in mouse Schwann cells
cAspAT is a new member of glyceroneogenesis, transcriptionally regulated by TZD via the control of RORalpha expression by PPARgamma (show PPARG Proteins) in adipocytes
These findings were largely obscured in intact mitochondria due to robust H2O2 scavenging and limited ability to control substrate concentrations in the matrix. We conclude that in mitochondria with inhibited complex I, malate/glutamate-stimulated ROS generation depends strongly on oxaloacetate removal and on the ability of KGDH to oxidize KG generated by AST.
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
aspartate aminotransferase 1
, aspartate aminotransferase, cytoplasmic
, aspartate transaminase 1
, cysteine aminotransferase, cytoplasmic
, cysteine transaminase, cytoplasmic
, glutamate oxaloacetate transaminase 1
, growth-inhibiting protein 18
, transaminase A
, glutamate oxaloacetate transaminase 1, soluble
, Aspartate aminotransferase
, glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
, aspartate aminotransferase
, Aspartate aminotransferase, cytoplasmic
, cytosolic aspartate aminotransferase
, glutamic-oxaloacetic transaminase 1, soluble
, putative aspartate aminotransferase, cytoplasmic 2