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RELMbeta-overexpression can facilitate invasion and migration of gastric carcinoma cells.
RELMbeta levels were increased in Abdominal aortic aneurysm patients in the serum and in the aortic tissue. Increased RELMbeta levels may be involved in the pathogenesis of A (show APP Proteins)AA formation and progress.
elevated RELM-beta expression in asthmatic airways contributes to airways remodelling at least partly by increasing fibroblast proliferation and differentiation with resulting deposition of extracellular matrix proteins.
It is concluded that proper exercise training prevents up-regulation of FIZZ1/RELMalpha induced by cigarette smoking, which may be involved in the mechanism of proper exercise training modulating airway hyperresponsiveness.
RELMbeta is abundantly expressed in foam cells within plaques and contributes to atherosclerosis development via lipid accumulation and inflammatory facilitation.
Epithelial cell derived Fizz1 transgene is sufficient to increase bone-marrow derived dendritic cells in the lungs.
RELM-beta may play an important role not only in animal models of airway remodelling, but also in human airway pathology.
RELM-beta has the potential to contribute to airway remodelling in diseases such as asthma by acting on epithelial cells to increase proliferation, mucin (show SLC13A2 Proteins) and growth factor production, at least partly via ERK/MAPK (show MAPK1 Proteins)-PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signalling pathways.
Data show that over-expression of RELMbeta abolishes the invasion, metastasis and angiogenesis of gastric cancer cells in vitro.
High RELMbeta is associated with colorectal cancer.
The goblet cell-derived RELM-beta drives spontaneous colitis in Muc2 (show MUC2 Proteins)-deficient mice by promoting commensal microbial dysbiosis.
lack of RELMbeta leads to increased colonic expression of T helper cell type-2 cytokines and IL-17 (show IL17A Proteins), associated with a reduced ability to maintain intestinal homeostasis
These data suggest the contribution of increases in RELMbeta in the gut (show GUSB Proteins) and Kupffer cells to NASH (show SAMSN1 Proteins) development, raising the possibility of RELMbeta being a novel therapeutic target for NASH (show SAMSN1 Proteins).
These data demonstrate that RELMalpha but not RELMbeta significantly impacts the immune response to N. brasiliensis infection by downregulating the Th2 adaptive immune response in the lung.
RELMbeta protein levels were upregulated in Angiotensin II-induced Abdominal aortic aneurysm mice.Immunohistochemical staining revealed abundant expression of RELMbeta in AAA (show AAAS Proteins) group, with scarce expression with saline treatment animals.
findings demonstrate that RELM-beta and goblet cells play an unexpected, yet critical role in recruiting CD4 (show CD4 Proteins)+ T cells to the colon to protect against an enteric pathogen
a novel role for GC-C (show GUCY2C Proteins) signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMbeta production
FIZZ2 is a T helper type (Th)2-associated multifunctional mediator with potentially important roles in the pathogenesis of fibrotic lung diseases.
, resistin-like beta
, resistin like beta
, colon and small intestine-specific cysteine-rich protein
, resistin-like protein beta
, C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2
, colon carcinoma-related gene protein
, cysteine-rich secreted A12-alpha-like protein 1
, cysteine-rich secreted protein A12-alpha-like 1
, cysteine-rich secreted protein FIZZ2
, found in inflammatory zone 1
, cysteine-rich secreted protein A12-beta
, found in inflammatory zone 2
, resistin-like molecule beta