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|Antigen||Vasoactive Intestinal Peptide (Vip) Antibodies|
|Reactivity||Cat (Feline), Fish, Human, Mammalian, Pig (Porcine), Rat (Rattus) Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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|Specificity||Reacts with VIP. The localization of the antigen is extracellular and cytoplasmic.|
|Cross-Reactivity (Details)||Species reactivity (tested):Most Mammals including Human, Pig, Cat, Rat, Mouse and Fish.|
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|Alternative Name||VIP Peptides (Vip Antibody Abstract)|
|Background||Located in the nerve fibers in the central and peripheral nervous system, VIP is probably acting as a neurotransmitter. The Verner-Morrison or Water Diarrhea Hypokalemia and Achlorhydria (WDHA) syndrome is a characteristic clinical syndrome associated with overproduction of VIP from endocrine tumors. VIP-producing tumors are usually neuroblastomas or endocrine tumors in the pancreas.Synonyms: VIP, Vasoactive intestinal peptide|
|Pathways||Hormone Activity, cAMP Metabolic Process|
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Immunohistochemistry on frozen sections, cell preparations and Paraffin embeddedsections (no pretreatment required). Working dilution: 1: 50 - 1: 100. Dilute immediately before use with PBS. Incubation time: 1 h at room temperature. Recommended positive control: Ileum.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the original vial at 2-8 °C and the reconstituted antibody (in aliquots) at -20 °C.|
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Karila, Holmgren: "Anally projecting neurons exhibiting immunoreactivity to galanin, nitric oxide synthase and vasoactive intestinal peptide, detected by confocal laser scanning microscopy, in the intestine of the Atlantic cod, Gadus morhua" in: Cell and tissue research, Vol. 287, Issue 3, pp. 525-33, 1997