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|Antigen||Adrenomedullin (ADM) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Adrenomedullin antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Product Details anti-Adrenomedullin AntibodyTarget Details Adrenomedullin Application Details Handling Images
|Specificity||This antibody detects endogenous levels of ADM protein. (region surrounding asn100)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Plasmids, Primers & others|
Target Details AdrenomedullinProduct Details anti-Adrenomedullin Antibody Application Details Handling Images back to top
|Background||Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.|
|Pathways||Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation|
Application DetailsProduct Details anti-Adrenomedullin Antibody Target Details Adrenomedullin Handling Images back to top
Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - -1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Adrenomedullin Antibody Target Details Adrenomedullin Application Details Images back to top
|Buffer||PBS, pH ~7.2, 0.05 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-Adrenomedullin Antibody Target Details Adrenomedullin Application Details Handling back to top