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Results show that VGF is epigenetically modified in human non-small-cell lung cancer (NSCLC) tissues if compared to tumor-free lung tissues, which results in an increased transcription and protein expression.
results suggest VGF enhances dendritic maturation and that these effects can be altered by common SNPs in the VGF gene
We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (show SYT4 Proteins), BAG3 (show BAG3 Proteins), APOA1 (show APOA1 Proteins), and VAV3 (show VAV3 Proteins), except for VGF protein, there was a trend between the expression of these four genes and their protein levels.
Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma.
Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls.
Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma (show ARHGEF16 Proteins) cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element
NERPs may be potent endogenous suppressors of glucose-dependent insulin (show INS Proteins) secretion.
DISC1 (show DISC1 Proteins) knockdown leads to a reduction of VGF in neurons.
Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance.
conclude that the metabolic profile of germline VGF knockout mice is largely the result of VGF ablation in embryonic CNS neurons
VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h (show SMARCA5 Proteins) cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival.
These observed changes in energy expenditure and food intake were associated with an increase in the hypothalamic contents of the VGF-derived peptides AQEE, TLQP and NERP-2. The complex phenotype of the VGF-/- mice is a likely consequence of global ablation of the gene and its derived peptides during development, as well as in the adult.
GnRH (show GNRH1 Proteins) stimulated the secretion of the VGF-derived peptide NERP1. NERP1 caused a concentration-dependent decrease in Fshb (show FSHB Proteins) gene induction.
results suggest hypothalamic VGF responds to environmental demands and plays an important role in energy balance and glycemic control likely acting in the melanocortin pathway downstream of BDNF (show BDNF Proteins).
Data indicate that high-fat diet induced obese mice showed reduced plasma VGF C-terminus, NAPPE and QQET-like (ERVW) peptide.
VGF expression is regulated by DISC1 (show DISC1 Proteins) through the activation of the PI3K/AKT (show AKT1 Proteins)/CREB (show CREB1 Proteins) pathway.
This study found that VGF expression, both mRNA and protein, was increased 1 h after training in the dorsal hippocampus.
Derived from the C-terminus of VGF, endogenous TLQP-21 peptide contributes to the mechanisms of spinal neuroplasticity after inflammation and nerve injury.
VGF has a role in adrenal large dense core vesicle formation and the regulation of catecholamine levels and blood pressure
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
VGF nerve growth factor inducible
, Neurosecretory protein VGF
, neuro-endocrine specific protein VGF
, neurosecretory protein VGF
, VGF8a protein