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stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose but reduced MEK/MAPK phosphorylation, reduced anchorage-independent growth, and modulated expressions of GLUT1 and Ras pathway related proteins.
The Authors reveal a gender difference in the prognostic value of concomitant AIB1 and HER2 (show ERBB2 Proteins) copy number gain (CNG (show CNGA1 Proteins)) in glioma patients which were barely noticed before. These observations indicated that genetic alterations synergistic with essential respects of sex determination influence glioma biology and patients outcomes.
NCOA3 maintained the molecular signature of chondrocytes dedifferentiating in vitro or exposed to IL-1 beta (show IL1B Proteins) and NCOA3 lose promotes posttraumatic OA at least partially by enhancing NF-kappaB (show NFKB1 Proteins) activation.
Data suggest that NEAT1, SRC3, and IGF1R (show IGF1R Proteins) are highly expressed in prostate cancer cells; NEAT1 appears to interact with SRC3 and promote cell proliferation via up-regulation of SRC3/IGF1R (show IGF1R Proteins)/AKT (show AKT1 Proteins) signaling pathway. (NEAT1 = nuclear paraspeckle assembly transcript-1; SRC3 = steroid receptor coactivator protein-3; IGF1R (show IGF1R Proteins) = insulin-like growth factor 1 receptor (show IGF1R Proteins))
findings suggest that the Warburg pathway enzyme PFKFB4 (show PFKFB4 Proteins) acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours
Findings demonstrate how SRC3 and Cx43 (show GJA1 Proteins) regulation between BMSCs and myeloma cells mediate cell growth and disease progression.
RAC3 (show RAC3 Proteins) bound tightly to the ARE enhancer region of the HO-1 (show HMOX1 Proteins) promoter via Nrf2 (show GABPA Proteins) binding.
Hypoxia inhibits the RAC3 gene expression leading to the autophagy process, allowing tumor cells to survive until angiogenesis occurs
RAC3 is an inhibitor of senescence whose downregulation in aged individuals could be probably a tumor suppressor mechanism.
The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 and EIF5A2 (show EIF5A2 Proteins) show promise for the noninvasive detection of bladder cancer. The model based on AIB1, EIF5A2 (show EIF5A2 Proteins), and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer.
differential expression of NCOA3 in pig intramuscular and subcutaneous adipose tissue is regulated by miR-17-5p.
findings show that SRC-3 contributes to host defense against enteric bacteria, at least in part via upregulating CXCL2 (show CXCL2 Proteins) expression to recruit neutrophils
Findings indicate that the Gata6 (show GATA6 Proteins) promoter is activated by Esrrb in association with Ncoa3, and Dax1 (show NR0B1 Proteins) inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
SRC-1 (show NCOA1 Proteins)/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (show SLC12A3 Proteins)-like abnormalities in the hearts of newborn and adult mice.
AIB1 promotes gastric cancer cell proliferation, survival and invasiveness through modulating major signaling pathways such as ErbB (show EGFR Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways. Findings suggest that AIB1 plays an important role in the pathogenesis of gastric cancer.
SRC-3 is a target for inhibiting aggressive prostate cancer containing neuroendocrine tumor cells.
Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC3 knockout mice.
The p/CIP gene regulatory network identifies various feed-forward modules including one in which p/CIP activates members of the extended pluripotency network, demonstrating that p/CIP is a component of this extended network.
Loss of SRC3 also shows sex differences in anxiety and exploratory behaviors.
IRS1 (show IRS1 Proteins) levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP and SRC-1 (show NCOA1 Proteins) deletions and in white adipose tissue and skeletal muscle of knockout mice.
Data show that knockdown of nuclear receptor coactivator 3 (Ncoa3) not only compromises the expression of pluripotency markers but also impairs in vitro and in vivo differentiation potential of embryonic stem cells.
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
nuclear receptor coactivator 3
, CBP-interacting protein
, amplified in breast cancer 1 protein
, class E basic helix-loop-helix protein 42
, receptor-associated coactivator 3
, steroid receptor coactivator protein 3
, thyroid hormone receptor activator molecule 1
, steroid receptor coactivator 3
, amplified in breast cancer-1 protein homolog
, retinoid X receptor-interacting coactivator xSRC-3