|Antigen||Ciliary Neurotrophic Factor Receptor (CNTFR) Antibodies|
|Epitope||Internal Region Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This CNTF Receptor alpha antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-CNTF Receptor alpha AntibodyTarget Details CNTF Receptor alpha Application Details Handling Images
|Specificity||This antibody reacts to CNTFR.|
Species reactivity (expected):Human, Rat, Canine.
Species reactivity (tested):Mouse.
|Immunogen||Peptide with sequence CRSNTYPKGFY, from the internal region of the protein sequence|
Target Details CNTF Receptor alphaProduct Details anti-CNTF Receptor alpha Antibody Application Details Handling Images back to top
|Alternative Name||CNTFR (CNTFR Antibody Abstract)|
|Background||CNTF Receptor alpha is a receptor belonging to the cytokine superfamily of receptors. Along with LIFR and gp130, CNTF Receptor alpha forms the heterotrimeric CNTF receptor complex. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. During signal transduction, CNTF first binds to CNTF Recepror alpha, and this permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.Synonyms: CNTFR, CNTFR alpha, Ciliary neurotrophic factor receptor alpha|
|Pathways||JAK-STAT Signaling, Feeding Behaviour|
Application DetailsProduct Details anti-CNTF Receptor alpha Antibody Target Details CNTF Receptor alpha Handling Images back to top
Peptide ELISA: 1/16000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CNTF Receptor alpha Antibody Target Details CNTF Receptor alpha Application Details Images back to top
|Buffer||Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|