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anti-Human EPOR Antibodies:
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Human Monoclonal EPOR Primary Antibody for cELISA, FACS - ABIN1720915
Winkelmann: The human erythropoietin receptor. in International journal of cell cloning 1993
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Human Polyclonal EPOR Primary Antibody for IF (p), IHC (p) - ABIN686347
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016
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Human Polyclonal EPOR Primary Antibody for ICC, IF - ABIN266926
Fairchild Benyo, Conrad: Expression of the erythropoietin receptor by trophoblast cellsin the human placenta. in Biology of reproduction 1999
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Human Monoclonal EPOR Primary Antibody for FACS - ABIN4896970
Farha, Asosingh, Xu, Sharp, George, Comhair, Park, Tang, Loyd, Theil, Tubbs, Hsi, Lichtin, Erzurum: Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities. in Blood 2011
Show all 2 Pubmed References
Human Monoclonal EPOR Primary Antibody for FACS - ABIN4896971
Pontikoglou, Liapakis, Pyrovolaki, Papadakis, Bux, Eliopoulos, Papadaki: Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. in Experimental hematology 2006
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Human Polyclonal EPOR Primary Antibody for ELISA, ICC - ABIN6261577
Chen, Li, Quan, Zhou, Zhao, Zhang, Hu, Hu: The Effects of Curcumae Longae Radix, Curcuma phaeocaulis Radix and Their Processed Products on Epo/EpoR Pathway and CD62p. in Frontiers in pharmacology 2018
Human Polyclonal EPOR Primary Antibody for WB - ABIN5664182
Kai-lan, Si: Pretreatment With Erythropoietin Attenuates Intestinal Ischemia Reperfusion Injury by Further Promoting PI3K/Akt Signaling Activation. in Transplantation proceedings 2016
Two novel missense mutations in EPOR gene causes erythrocytosis in two unrelated patients.
Here, we present two crystal structures of the human JAK2 FERM and SH2 domains bound to Leptin receptor (LEPR) and Erythropoietin receptor (EPOR), which identify a novel dimeric conformation for JAK2.
EpoR role in the proliferation and survival of non-small cell lung cancer cells
These results highlight the high intrinsic specificity of transmembrane domain interactions, demonstrate that a single methyl group can dictate specificity, and define the minimal chemical difference that can modulate the specificity of transmembrane domain interactions and the activity of transmembrane proteins.
Study reports for the first evidence that EPOR modulates breast cancer cell morphology changes upon tamoxifen treatment, which result in increased formation of cell protrusions and subsequent cell death and, proposes sustained AKT phosphorylation in EPOR-overexpressing cells as a mechanism that can lead to EPOR-induced tamoxifen resistance.
Authors retrospectively investigated whether TFR2 isoforms and EPOR are differentially expressed in MDS patients and whether the expression is associated with patients' clinical outcomes.
High EPOR expression is associated with monoclonal gammopathy of undetermined significance and multiple myeloma.
EPO-mediated EPOR signaling reduced the viability of myeloma cell lines and of malignant primary plasma cells in vitro
this study shows that EPO could directly promote tumor progression via EPO receptor-expressing macrophages
No evidence of in vivo activation of the Epo-R in WAT could be documented despite detectable levels of Epo-R mRNA. CONCLUSION: Thus, in contradiction to animal studies, Epo treatment within a physiological relevant range in humans does not exert direct effects in a subcutaneous WAT.
Our results suggest that EPO/EPOR pathway promotes gastric cancer formation, proliferation, migration, and decreases apoptosis
These results suggest that both EpoR-positive and EpoR-negative cancer cells could be regulated by exogenous Epo. However, an increased response to erythropoietin was observed in the EpoR-positive cells. Thus, erythropoietin increases the risk of tumor progression in colon cancer and should not be used to treat anemia in this type of cancer.
Overexpression of EPOR is associated with clear cell renal cell carcinoma.
HIF-1alpha and EPO-R may be an indicator of the aggressiveness of invasive breast cancers
In multivariate survival analysis, age, Epo and EpoR were independent prognostic factors related to overall survival in hepatocellular carcinoma.
These results identify EPOR as the secondbona fidehydroxylation-dependent substrate of VHL that potentially influences oxygen homeostasis and contributes to the complex genotype-phenotype correlation in VHL disease.
We report for a first time that functional EpoR is expressed in human rhabdomyosarcoma cell lines as well as by primary tumors from RMS patients.
erythrocyte lineage enforces exclusivity through upregulation of EKLF and its lineage-specific cytokine receptor (EpoR) while inhibiting both FLI-1 and the receptor TpoR (also known as MPL) for the opposing megakaryocyte lineage
A new point mutation in EPOR induces a short deletion in congenital erythrocytosis.
Data show that erythropoietin receptor antagonist EMP9 suppressed hemoglobin synthesis in xenografts of HeLa cells.
CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK.
these results have revealed that phosphorylation of Tyr-343, Tyr-460, and Tyr-464 in EpoR underlies JAK2 V617F mutant-induced tumorigenesis.
A solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising the transmembrane domain and the juxtamembrane regions reconstituted in dodecylphosphocholine (DPC) micelles.
loss of function results in defective macrophage clearance of apoptotic cells in vivo
These data indicate that EpoR signaling is associated with cardiac remodeling following chronic iron deficiency.
We propose that the CID-dependent dimerization system combined with the EpoR intracellular domain and the Gata1 gene regulatory region generates a novel peroral strategy for the treatment of anemia.
transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles
EpoR and its activity are downstream effectors of Klotho enabling it to function as a cytoprotective protein against oxidative injury.
Expression of EPOR in rod photoreceptors, Muller cells, and amacrine, horizontal, and ganglion cells of the peripheral retina is not required for the maturation, function, and survival of these cells in aging tissue.
Data indicate a Cbl/p85/epsin-1 pathway in erythropoietin receptor (EpoR) endocytosis.
Data from knockout mice suggest that adipose tissue-specific disruption of EPO receptor does not alter adipose tissue expansion, adipocyte morphology, insulin resistance, inflammation, or angiogenesis.
the EPO-EPOR system may play a role in glucose metabolism within adipocytes.
EPOR regulates transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO-dependent erythroblast formation.
These findings reveal a role of endogenous EPO/EPOR for cognition, at least in schizophrenic patients.
expression of EPOR decreased with the development of renal cortex
enhanced activation of signaling pathways downstream of the EPO-receptor, indicate that SH2B1 is a negative regulator of EPO signaling.
Studies implicate Spry1 as a novel regulator of erythropoiesis during anemia, transducer of EPO/EPOR signals, and candidate suppressor of Jak2 activity.
EPO/EPOR signaling from astrocyte to oligodendrocyte progenitor cells (OPC) prevents OPC damage under hypoxic/reoxygenation conditions.
Postmortem neural precursor cells differentiate mostly in self-renewable neurons, show activation, and express both erythropoietin (EPO) and its receptor (EPO-R).
expressed in both non-wounded and wounded skin tissue as well as in fibroblasts and keratinocytes
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
, Erythropoietin receptor
, type I single-transmembrane cytokine receptor
, erythropoietin receptor-like