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Human EPOR ELISA Kit for Sandwich ELISA - ABIN414365
Villafuerte, Macarlupú, Anza-Ramírez, Corrales-Melgar, Vizcardo-Galindo, Corante, León-Velarde: Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness. in Journal of applied physiology (Bethesda, Md. : 1985) 2014
Show all 2 Pubmed References
High EPOR expression is associated with monoclonal gammopathy of undetermined significance and multiple myeloma.
EPO (show EPO ELISA Kits)-mediated EPOR signaling reduced the viability of myeloma cell lines and of malignant primary plasma cells in vitro
this study shows that EPO (show EPO ELISA Kits) could directly promote tumor progression via EPO (show EPO ELISA Kits) receptor-expressing macrophages
No evidence of in vivo activation of the Epo-R in WAT could be documented despite detectable levels of Epo-R mRNA. CONCLUSION: Thus, in contradiction to animal studies, Epo (show EPO ELISA Kits) treatment within a physiological relevant range in humans does not exert direct effects in a subcutaneous WAT.
Our results suggest that EPO (show EPO ELISA Kits)/EPOR pathway promotes gastric cancer formation, proliferation, migration, and decreases apoptosis
These results suggest that both EpoR-positive and EpoR-negative cancer cells could be regulated by exogenous Epo (show EPO ELISA Kits). However, an increased response to erythropoietin (show EPO ELISA Kits) was observed in the EpoR-positive cells. Thus, erythropoietin (show EPO ELISA Kits) increases the risk of tumor progression in colon cancer and should not be used to treat anemia in this type of cancer.
Overexpression of EPOR is associated with clear cell renal cell carcinoma.
HIF-1alpha (show HIF1A ELISA Kits) and EPO-R may be an indicator of the aggressiveness of invasive breast cancers
In multivariate survival analysis, age, Epo (show EPO ELISA Kits) and EpoR were independent prognostic factors related to overall survival in hepatocellular carcinoma.
These results identify EPOR as the secondbona fidehydroxylation-dependent substrate of VHL (show VHL ELISA Kits) that potentially influences oxygen homeostasis and contributes to the complex genotype-phenotype correlation in VHL (show VHL ELISA Kits) disease.
CIS (show CISH ELISA Kits) interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 (show STAT5A ELISA Kits) and ERK (show EPHB2 ELISA Kits).
these results have revealed that phosphorylation of Tyr (show TYR ELISA Kits)-343, Tyr (show TYR ELISA Kits)-460, and Tyr (show TYR ELISA Kits)-464 in EpoR underlies JAK2 (show JAK2 ELISA Kits) V617F mutant-induced tumorigenesis.
A solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising the transmembrane domain and the juxtamembrane regions reconstituted in dodecylphosphocholine (DPC) micelles.
These data indicate that EpoR signaling is associated with cardiac remodeling following chronic iron deficiency.
We propose that the CID (show CENPA ELISA Kits)-dependent dimerization system combined with the EpoR intracellular domain and the Gata1 (show GATA1 ELISA Kits) gene regulatory region generates a novel peroral strategy for the treatment of anemia.
transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles
EpoR and its activity are downstream effectors of Klotho (show KL ELISA Kits) enabling it to function as a cytoprotective protein against oxidative injury.
Expression of EPOR in rod photoreceptors, Muller cells, and amacrine, horizontal, and ganglion cells of the peripheral retina is not required for the maturation, function, and survival of these cells in aging tissue.
Data indicate a Cbl (show CBL ELISA Kits)/p85 (show ECM1 ELISA Kits)/epsin-1 (show EPN1 ELISA Kits) pathway in erythropoietin receptor (EpoR) endocytosis.
Data from knockout mice suggest that adipose tissue-specific disruption of EPO (show EPO ELISA Kits) receptor does not alter adipose tissue expansion, adipocyte morphology, insulin (show INS ELISA Kits) resistance, inflammation, or angiogenesis.
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
, Erythropoietin receptor
, type I single-transmembrane cytokine receptor
, erythropoietin receptor-like