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The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
sIL (show PMEL Proteins)-6R may be a useful biomarker to assess insulin (show INS Proteins) resistance among morbidly obese subjects
Study identified variants associated with the age of onset of Alzheimer's disease in APOE (show APOE Proteins) varepsilon4 carriers. Across five datasets, p.D358A had a meta P = 3 x10-4 and an odds ratio = 1.3, 95% confidence interval 1.12 -1.48. Study suggests that a common coding region variant of the IL-6 (show IL6 Proteins) receptor results in neuroinflammatory changes that may influence the age of onset of Alzheimer's disease in APOE (show APOE Proteins) varepsilon4 carriers.
IL-6R protein expression on plasma membrane of ovarian cancer cells mediates enhanced cell migration/invasiveness in response to IL6 (show IL6 Proteins) in ascites.
IL6R protein levels were higher in bone than in lymph node and visceral metastases of castration-resistant prostate cancer.
study focused on IL-6 (show IL6 Proteins) and activation of its receptors gp80 (show CLU Proteins) and gp130 (show IL6ST Proteins) in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (show FBXL15 Proteins) Kit, Unifast, and Duralay on control of inflammation
In the present study, the authors show that deletion of a triple serine (3S) motif (Ser (show SIGLEC1 Proteins)-359 to Ser (show SIGLEC1 Proteins)-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17 (show ADAM17 Proteins), but not ADAM10 (show ADAM10 Proteins). We find that the impaired shedding is caused by the reduced distance between the cleavage site and the plasma membrane.
IL6R SNPs are associated with simultaneously high CRP (show CRP Proteins), LDL and ApoB (show APOB Proteins) levels.
The sgp130, IL-6 (show IL6 Proteins), and sIL (show PMEL Proteins)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (show IL6 Proteins) trans-signaling pathway to the pathophysiology of DR.
The mRNA expression of IL6R was inversely correlated with miR (show MLXIP Proteins)-449a in osteosarcoma tissues. In addition, JAK1 (show JAK1 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway was regulated by circ_0009910/miR (show MLXIP Proteins)-449a/IL6R axis.
IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis
IL-6sR and gp130 (show ANPEP Proteins), but not IL-6R alpha, play important roles in regulation of granulosa cell survival
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6 (show IL6 Proteins)/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.
role for IL-6R expression in regulating RBC (show CACNA1C Proteins) alloimmunization
There are functional interleukin-6 receptor-alpha on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 (show IL6 Proteins) decreases obesity in mice via an effect on this cell type.
we present evidence for the role of M2 phenotype TAM (show CCNA1 Proteins) in IL-6 (show IL6 Proteins) receptor-mediated signals, particularly tyrosine phosphorylation of STAT3 (show STAT3 Proteins), responsible for the prosurvival adaptation of tumor cells to hypoxia.
TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Proteins), DNAX-activation protein 12 (show TYROBP Proteins), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 Proteins) and PTPN22 (show PTPN22 Proteins) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Proteins) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Proteins)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Proteins) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Proteins)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
interleukin 6 receptor
, interleukin 6 receptor alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, IL-6 receptor subunit alpha
, IL-6R 1
, membrane glycoprotein 80
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, IL-6 receptor alpha chain