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The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
The expression of STOML2, a gene that plays a key role in mitochondrial function and T-cell activation, is associated with both IL-6 (show IL6 Proteins) signaling and asthma risk.
IL6R is downregulated in the tissues from colonic biopsies taken from Ulcerative Colitis patients.Thus, expression levels of IL6R can be used as markers of disease or disease progression in Ulcerative Colitis patients.
expanded CD8 (show CD8A Proteins)(+)IL-6Ralpha(low) EM T cells have roles in coronary artery disease through their pro-inflammatory and highly cytotoxic capacities
Both gingival crevicular fluid sIL (show PMEL Proteins)-6R and calprotectin (show S100A8 Proteins) concentrations are significant biomarkers in the evaluation of periodontal inflammation
Data show that the let-7c/miR (show MLXIP Proteins)-99a/miR (show MLXIP Proteins)-125b cluster controlled tumorigenesis by targeting IL-6 (show IL6 Proteins), IL-6R and IGF1R (show IGF1R Proteins).
Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf (show MAF Proteins) induction were adverse events for counteracting tumor-specific Th1 (show TH1L Proteins) generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 (show ADAM17 Proteins) in regulating murine IL-6 (show IL6 Proteins) signals during inflammatory processes.
this study show that soluble IL-6R is infiltrating from the circulation in an ADAM17 (show ADAM17 Proteins)-independent process and is involved in the controlled resolution of an acute inflammatory episode
the sIL (show PMEL Proteins)-6R/p28 (show PSMD10 Proteins) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (show AFT1 Proteins) to the IFN-lambda1 promoter via the p38 MAPK (show MAPK14 Proteins) signaling pathway; results demonstrate the important role of sIL (show PMEL Proteins)-6R/p28 (show PSMD10 Proteins) FP in mediating virus-induced type III IFN production
Thus, trans-signaling of IL-6 can only occur via sIL-6R, but not sCD5.
IL-6sR and gp130 (show ANPEP Proteins), but not IL-6R alpha, play important roles in regulation of granulosa cell survival
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6 (show IL6 Proteins)/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.
TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Proteins), DNAX-activation protein 12 (show TYROBP Proteins), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 Proteins) and PTPN22 (show PTPN22 Proteins) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Proteins) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Proteins)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Proteins) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Proteins)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (show IL6 Proteins) binds to Il-6Ralpha in brain the effect is pyrogenic.
metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 Proteins) as well as soluble IL-6Ra, which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.
Cellular senescence or EGFR (show EGFR Proteins) signaling induces Interleukin 6 receptor expression controlled by mTOR (show FRAP1 Proteins).
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
interleukin 6 receptor
, interleukin 6 receptor alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, IL-6 receptor subunit alpha
, IL-6R 1
, membrane glycoprotein 80
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, IL-6 receptor alpha chain