anti-Mouse (Murine) IL12 antibody for Functional Studies

Recommended IL12 Antibody (supplied by: Log in to see )

Antigen
Interleukin 12 (IL12) Antibodies
  • CLMF
  • CLMF2
  • IL-12B
  • NKSF
  • NKSF2
  • p40
  • Il-12b
  • Il12p40
  • Il-12p40
  • Il12
  • IL-12p40
  • IL-12
  • LOC100217488
  • IL-12p35
  • Il-12a
  • Ll12a
  • p35
  • IL12p40
  • IL12B
  • IL-12 p35
  • interleukin 12B
  • interleukin 12A
  • interleukin 12b
  • interleukin 12a
  • Interleukin 12 level
  • IL12B
  • IL12A
  • Il12b
  • Il12a
  • IL12
  • il12a
Reactivity
Mouse (Murine)
175
75
16
9
5
2
2
2
1
1
1
1
Host
Rat
125
45
44
44
2
1
Clonality
Monoclonal
Conjugate
This IL12 antibody is un-conjugated
34
14
10
9
8
5
5
4
4
4
4
4
4
4
4
4
4
3
2
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
170
168
83
41
29
18
18
13
11
11
7
6
6
5
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
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Pubmed
5 references available

Available images

ELISA image for anti-Interleukin 12 (IL12) antibody (ABIN2665104)
Catalog No. ABIN2665104
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2665103 Func FACS IHC WB Rat IgG2a kappa Log in to see C18-2 5
1 ABIN2474926 Func ELISA WB Goat IgG Log in to see Polyclonal 0
1 ABIN291626 Func Neut ELISA WB Goat IgG Log in to see Polyclonal 0
1 ABIN645705 Func IP IHC ELISA WB Rat IgG2b Log in to see 0

General

Antigen Interleukin 12 (IL12) Antibodies
Reactivity Mouse (Murine)
(175), (75), (16), (9), (5), (2), (2), (2), (1), (1), (1), (1)
Host Rat
(125), (45), (44), (44), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL12 antibody is un-conjugated
(34), (14), (10), (9), (8), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
(170), (168), (83), (41), (29), (18), (18), (13), (11), (11), (7), (6), (6), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-IL12 Antibody

Target Details IL12 Application Details Handling References for anti-IL12 antibody (ABIN2665104) Images
Purification The antibody was purified by affinity chromatography.
Clone C18-2
Isotype IgG2a kappa

Target Details IL12

Product Details anti-IL12 Antibody Application Details Handling References for anti-IL12 antibody (ABIN2665104) Images back to top
Antigen
Alternative Name IL-12 (IL12 Antibody Abstract)
Background Interleukin 12 (IL-12) is a heterodimeric pleiotropic 70 kD (p70) cytokine consisting of a 40 kD (p40) subunit and a 35 kD (p35) subunit. IL-12 is a potent regulator of cell-mediated immune responses and key mediator of Th1 cell development. Bioactive IL-12 is secreted by activated B lymphocytes, dendritic cells, and macrophages in response to pathogens or upon interaction with activated T cells.IL-12 p70 stimulates cytotoxic T, NK and LAK cell proliferation, andinduces IFN-γ and TNF production in resting and activated T and NK cells.It has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular-immunity and as an anti-tumor and anti-viral agent.
Pathways JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation

Application Details

Product Details anti-IL12 Antibody Target Details IL12 Handling References for anti-IL12 antibody (ABIN2665104) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL12 Antibody Target Details IL12 Application Details References for anti-IL12 antibody (ABIN2665104) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL12 antibody (ABIN2665104)

Product Details anti-IL12 Antibody Target Details IL12 Application Details Handling Images back to top
Background publications

Lankford, Frucht: "A unique role for IL-23 in promoting cellular immunity." in: Journal of leukocyte biology, Vol. 73, Issue 1, pp. 49-56, 2003

Parham, Chirica, Timans, Vaisberg, Travis, Cheung, Pflanz, Zhang, Singh, Vega, To, Wagner, OFarrell, McClanahan, Zurawski, Hannum, Gorman, Rennick, Kastelein, de Waal Malefyt, Moore: "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 11, pp. 5699-708, 2002

Trinchieri, Wysocka, DAndrea, Rengaraju, Aste-Amezaga, Kubin, Valiante, Chehimi: "Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation." in: Progress in growth factor research, Vol. 4, Issue 4, pp. 355-68, 1993

Trinchieri: "Interleukin-12 and its role in the generation of TH1 cells." in: Immunology today, Vol. 14, Issue 7, pp. 335-8, 1993

Quesniaux: "Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview." in: Research in immunology, Vol. 143, Issue 4, pp. 385-400, 1992

Images

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Supplier Images
ELISA image for anti-Interleukin 12 (IL12) antibody (ABIN2665104) anti-Interleukin 12 (IL12) antibody