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|Antigen||Interleukin 9 Receptor (IL9R) Antibodies|
|Epitope||AA 1-270 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This IL9 Receptor antibody is un-conjugated Alternatives|
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Product Details anti-IL9 Receptor AntibodyTarget Details IL9 Receptor Application Details Handling Images
|Specificity||Rat IL9R / Interleukin 9 receptor|
|Characteristics||This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL9R / Interleukin 9 receptor (rR IL9R / Interleukin 9 receptor, ABIN2009126 EDM04022.1, Met1-Ala270,.|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Rat IL9R / Interleukin 9 receptor protein (ABIN2009126)|
Target Details IL9 ReceptorProduct Details anti-IL9 Receptor Antibody Application Details Handling Images back to top
|Alternative Name||IL9R (IL9R Antibody Abstract)|
|Background||Interleukin 9 receptor (IL9R / Interleukin 9 receptor), also known as CD129 (Cluster of Differentiation 129), is a type I cytokine receptor. The IL9R / Interleukin 9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signal transduction. Interleukin-9 (IL-9) exerts its pleiotropic effects through the IL9R / Interleukin 9 receptor complex that consists of the ligand specific IL-9R α-chain, and the IL-2R γ-chain. IL9 is a multifunctional cytokine released by T cells. Various observations indicate that IL-9 is actively involved in mast cells responses by inducing the proliferation and differentiation of these cells. Other potential biological targets for IL-9 include B lymphocytes, and hematopoietic progenitors, for which higher responses were observed with foetal or transformed cells as compared to normal adult progenitors. It has been identified that IL9R / Interleukin 9 receptor is constitutively related with JAk1. Activated STAT complexes induced by IL-9 were found to contain STAT1, STAT3, and STAT5 transcription factors. A single tyrosine of the IL-9 receptor, required for activation of three different STAT proteins, is necessary for distinct activities of this cytokine, including proliferative responses.|
|Research Area||Immunology, Adaptive Immunity, CD Antigens|
|Pathways||JAK-STAT Signaling, Growth Factor Binding|
Application DetailsProduct Details anti-IL9 Receptor Antibody Target Details IL9 Receptor Handling Images back to top
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat IL9R. The detection limit for Rat IL9R is approximately 0.0049 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL9 Receptor Antibody Target Details IL9 Receptor Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|