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|Antigen||Myeloproliferative Leukemia Virus Oncogene (MPL) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Conjugate||This MPL antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-MPL AntibodyTarget Details MPL Application Details Handling References for anti-MPL antibody (ABIN967682) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human c-Mpl extracellular domain|
Target Details MPLProduct Details anti-MPL Antibody Application Details Handling References for anti-MPL antibody (ABIN967682) Images back to top
|Alternative Name||CD110 (MPL Antibody Abstract)|
The 1.78.1 monoclonal antibody specifically binds to the human Thrombopoietin Receptor (TPO-R) that is also know as the Myeloproliferative leukemia protein (c-Mpl) or CD110. CD110 is a type I transmembrane protein and a member of the hematopoietin receptor family. It is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage and platelets. CD110 serves as a receptor for thrombopoietin. Upon binding of thrombopoietin to CD110, megakaryocyte proliferation and differentiation is induced and stem cells are protected from apoptosis.
Synonyms: C-MPL, MPL, MPLV, TPOR, Thrombopoietin receptor
|Molecular Weight||65-72 kDa (HEL cells) and 80-90 kDa (Platelets)|
Application DetailsProduct Details anti-MPL Antibody Target Details MPL Handling References for anti-MPL antibody (ABIN967682) Images back to top
Related Products: ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-MPL Antibody Target Details MPL Application Details References for anti-MPL antibody (ABIN967682) Images back to top
|Buffer||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at 4°C.|
References for anti-MPL antibody (ABIN967682)Product Details anti-MPL Antibody Target Details MPL Application Details Handling Images back to top
|Product cited in:||
Abbott, Huang, Ellison, Chen, Arora, Szilvassy, Wei: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." in: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, 2010
Deng, Banu, Malloy, Hass, Wang, Cavacini, Eaton, Avraham: "An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis." in: Blood, Vol. 92, Issue 6, pp. 1981-8, 1998
Gotoh, Ritchie, Takahira, Broxmeyer: "Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells." in: Annals of hematology, Vol. 75, Issue 5-6, pp. 207-13, 1998
Broudy, Lin, Fox, Taga, Saito, Kaushansky: "Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit." in: Blood, Vol. 88, Issue 6, pp. 2026-32, 1996
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