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|Antigen||Oncostatin M Receptor (OSMR) Antibodies|
|Epitope||AA 1-738 Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This Oncostatin M Receptor antibody is un-conjugated Alternatives|
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Product Details anti-Oncostatin M Receptor AntibodyTarget Details Oncostatin M Receptor Application Details Handling Images
|Specificity||Mouse OSMR / IL-31RB|
|Characteristics||Produced in rabbits immunized with purified, recombinant Mouse OSMR / IL-31RB (rM OSMR / IL-31RB, ABIN2007900 O70458-1, Met 1-Leu 738,. Total IgG was purified by Protein A affinity chromatography.|
|Purification||purified by Protein A affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Mouse OSMR / IL-31RB protein (ABIN2007900)|
Target Details Oncostatin M ReceptorProduct Details anti-Oncostatin M Receptor Antibody Application Details Handling Images back to top
|Alternative Name||OSMR (OSMR Antibody Abstract)|
|Background||Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.|
|Pathways||JAK-STAT Signaling, Growth Factor Binding|
Application DetailsProduct Details anti-Oncostatin M Receptor Antibody Target Details Oncostatin M Receptor Handling Images back to top
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse OSMR. The detection limit for Mouse OSMR is approximately 0.00975 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Oncostatin M Receptor Antibody Target Details Oncostatin M Receptor Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|