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Human PTPN11 Protein expressed in Wheat germ - ABIN1316822
Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
, protein-tyrosine phosphatase 1D
, protein-tyrosine phosphatase 2C
, tyrosine-protein phosphatase non-receptor type 11
, SH2 domain-containing protein tyrosine phosphatase-2
, protein-tyrosine phosphatase SYP
, SH-PTP2 protein tyrosine phosphatase non-receptor type 11
, SH-PTP2 protein tyrosine phosphatase, non-receptor type 11
, encodes catalytic domain
, protein tyrosine phosphatase SH-PTP2
, protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
, non-receptor type protein tyrosine phosphatase SHP2