anti-Mouse (Murine) PTPN6 antibody for Immunohistochemistry

Recommended PTPN6 Antibody (supplied by: Log in to see )

Antigen
Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
  • HCPH
  • HPTP1C
  • PTP-1C
  • SH-PTP1
  • SHP-1
  • SHP-1L
  • SHP1
  • DRPLA
  • Hcph
  • Ptp1C
  • me
  • motheaten
  • Ptph6
  • Shp-1
  • fj22f05
  • wu:fj22f05
  • zgc:55501
  • ptpn6
  • protein tyrosine phosphatase, non-receptor type 6
  • protein tyrosine phosphatase, non-receptor type 6 L homeolog
  • PTPN6
  • Ptpn6
  • ptpn6
  • ptpn6.L
Reactivity
Mouse (Murine), Rat (Rattus), Human
231
100
91
5
4
2
2
2
1
1
1
1
1
Host
Rabbit
156
41
35
Clonality
Polyclonal
Conjugate
This PTPN6 antibody is un-conjugated
9
9
8
3
3
3
3
3
3
3
3
3
3
3
3
3
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
169
104
72
40
39
37
22
11
8
8
7
5
2
1
Options
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Available images

Catalog No. ABIN3021975
$ 393.25
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
19 ABIN5997090 IHC WB Rabbit IgG Log in to see 0
15.971891 ABIN6255949 ELISA ICC IF IHC WB Rabbit IgG pTyr536 Log in to see Polyclonal 0
15.971891 ABIN6269987 ELISA IHC WB Rabbit IgG pSer534 Log in to see Polyclonal 0
15.971891 ABIN6265073 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
15.576219 ABIN3186951 ELISA IHC WB Rabbit IgG Thr47 Log in to see Polyclonal 0
15.576219 ABIN3182468 ELISA IHC WB Rabbit IgG pTyr536 Log in to see Polyclonal 0
13 ABIN1874455 IF IHC WB Rabbit IgG Log in to see Polyclonal 0
12.971891 ABIN6264520 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
12.971891 ABIN2422133 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0
12.576219 ABIN1842510 IF IHC WB Rabbit IgG pTyr536 Log in to see Polyclonal 0
12.576219 ABIN967022 IHC Rabbit Log in to see Polyclonal 0
9.971891 ABIN1531195 IHC ELISA WB Rabbit IgG AA 502-551, pTyr536 Log in to see Polyclonal 0
9.971891 ABIN1532211 IHC ELISA WB Rabbit IgG AA 502-551 Log in to see Polyclonal 0
9.971891 ABIN6256764 IHC WB Rabbit IgG pTyr564 Log in to see Polyclonal 0
9.971891 ABIN1870549 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal 0
7 ABIN2988270 IF/ICC IHC Rabbit IgG pTyr536 Log in to see Polyclonal 0
7 ABIN274221 IF IHC WB Rabbit IgG Log in to see Polyclonal 0
6.9718914 ABIN1103855 ELISA IHC IHC (p) WB Goat AA 553-564 Log in to see Polyclonal 0
4 ABIN2888577 ELISA IHC WB Rabbit IgG AA 502-551 Log in to see Polyclonal 0
4 ABIN273701 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal 0

General

Antigen Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
Reactivity Mouse (Murine), Rat (Rattus), Human
(231), (100), (91), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(156), (41), (35)
Clonality
Polyclonal
Conjugate This PTPN6 antibody is un-conjugated
(9), (9), (8), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(169), (104), (72), (40), (39), (37), (22), (11), (8), (8), (7), (5), (2), (1)
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Product Details anti-PTPN6 Antibody

Target Details PTPN6 Application Details Handling Images
Purification Affinity purification
Immunogen Recombinant protein of human PTPN6
Isotype IgG
Plasmids, Primers & others

Target Details PTPN6

Product Details anti-PTPN6 Antibody Application Details Handling Images back to top
Antigen
Alternative Name PTPN6 (PTPN6 Antibody Abstract)
Background SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation. Because SHP-1 downregulates various proliferation pathways, SHP-1 is considered a potential tumor suppressor and angiogenesis regulator.
Synonyms: PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, SH-PTP1
Gene ID 5777
UniProt P29350
Pathways JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2

Application Details

Product Details anti-PTPN6 Antibody Target Details PTPN6 Handling Images back to top
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only

Handling

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Images back to top
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C

Images

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling back to top
Supplier Images
Immunofluorescence (IF) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibody (ABIN3021975) Immunofluorescence analysis of MCF-7 cell using PTPN6 antibody.
Immunofluorescence (IF) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibody (ABIN3021975) Immunofluorescence analysis of U2OS cell using PTPN6 antibody. Blue: DAPI for nuclear...
Western Blotting (WB) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibody (ABIN3021975) Western blot analysis of extracts of various cell lines, using PTPN6 antibody.
Immunofluorescence (IF) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibody (ABIN3021975) Immunofluorescence analysis of U2OS cells using PTPN6 antibody.