KIR2DL1 Products
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1))
Categories
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].
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Featured KIR2DL1 Categories
KIR2DL1 Antibodies
High quality antibodies with extensive validation data.
KIR2DL1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KIR2DL1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7157495
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
- (2)
Cat. No.
ABIN165422
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, ICC, IF
Validations
- (2)
- (1)
Cat. No.
ABIN532938
Quantity
100 μL
Datasheet
Datasheet
Recommended KIR2DL1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730430
Quantity
96 tests
Datasheet
Datasheet
Recommended KIR2DL1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275084
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275085
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308691
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our KIR2DL1 products
: "Eomesodermin and T-bet mark developmentally distinct human natural killer cells." in: JCI insight, Vol. 2, Issue 5, pp. e90063, (2017) (PubMed).: "NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 7, pp. 2762-71, (2016) (PubMed).
: "New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells." in: Journal of leukocyte biology, Vol. 100, Issue 3, pp. 471-9, (2016) (PubMed).
: "Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 9, pp. 4524-36, (2015) (PubMed).
: "The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 7, pp. 3262-72, (2015) (PubMed).
: "2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells." in: Genes and immunity, Vol. 16, Issue 5, pp. 301-10, (2015) (PubMed).
: "Uptake of CCR7 by KIR2DS4⁺ NK cells is induced upon recognition of certain HLA-C alleles." in: Journal of immunology research, Vol. 2015, pp. 754373, (2015) (PubMed).
: "Tissue-Specific Education of Decidual NK Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 7, pp. 3026-32, (2015) (PubMed).
: "Coordinated expression of DNAM-1 and LFA-1 in educated NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 9, pp. 4518-27, (2015) (PubMed).
: "Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 6, pp. 2467-71, (2015) (PubMed).
Synonyms and alternative names related to KIR2DL1
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 (KIR2DL1), killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 (KIR2DL1), CD158A, KIR-K64, KIR221, NKAT, NKAT1, p58.1Protein level used designations for KIR2DL1
- CD158 antigen-like family member A
- MHC class I NK cell receptor
- NKAT-1
- killer Ig receptor
- killer cell immunoglobulin-like receptor 2DL1
- killer inhibitory receptor 2-2-1
- natural killer-associated transcript 1
- p58 NK cell inhibitory receptor NKR-K6
- p58 NK receptor CL-42/47.11
- p58 killer cell inhibitory receptor KIR-K64
- p58 natural killer cell receptor clones CL-42/47.11
- p58.1 MHC class-I-specific NK receptor
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