KIR2DS3 Products
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 3 (KIR2DS3))
Categories
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].
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Featured KIR2DS3 Categories
KIR2DS3 Antibodies
High quality antibodies with extensive validation data.
KIR2DS3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KIR2DS3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN651950
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF
Validations
- (1)
Cat. No.
ABIN7157515
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN517338
Quantity
100 μg
Datasheet
Datasheet
Recommended KIR2DS3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3082503
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3099945
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2724259
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our KIR2DS3 products
: "Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule." in: Genes and immunity, Vol. 10, Issue 2, pp. 162-73, (2009) (PubMed).Synonyms and alternative names related to KIR2DS3
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), NKAT7Protein level used designations for KIR2DS3
- MHC class I NK cell receptor
- NKAT-7
- killer cell immunoglobulin-like receptor 2DS3
- natural killer cell inhibitory receptor
- natural killer-associated transcript 7
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