KIR2DS5 Products
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5 (KIR2DS5))
Categories
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
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Recommended KIR2DS5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IF
Validations
- (1)
Cat. No.
ABIN7157520
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, ICC
Validations
- (1)
Cat. No.
ABIN6262820
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (1)
Cat. No.
ABIN6241920
Quantity
100 μL
Datasheet
Datasheet
Recommended KIR2DS5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN3170494
Quantity
10 μg
Datasheet
Datasheet
Synonyms and alternative names related to KIR2DS5
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 (KIR2DS5), CD158G, NKAT9Protein level used designations for KIR2DS5
- CD158 antigen-like family member G
- MHC class I NK cell receptor
- NKAT-9
- killer cell immunoglobulin-like receptor 2DS5
- natural killer cell inhibitory receptor
- natural killer-associated transcript 9
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