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|Antigen||Microtubule-Associated Protein tau (MAPT) Antibodies|
|Conjugate||This MAPT antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-MAPT AntibodyTarget Details MAPT Application Details Handling References for anti-MAPT antibody (ABIN356907) Images
|Specificity||This antibody detects TAU (MAPT).|
|Purification||Protein A column, followed by peptide affinity purification.|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S720 of human MAPT.|
Target Details MAPTProduct Details anti-MAPT Antibody Application Details Handling References for anti-MAPT antibody (ABIN356907) Images back to top
|Alternative Name||MAPT / tau (MAPT Antibody Abstract)|
|Background||MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau|
|Molecular Weight||78878 Da|
|Gene ID||4137, 9606|
|Pathways||MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size|
Application DetailsProduct Details anti-MAPT Antibody Target Details MAPT Handling References for anti-MAPT antibody (ABIN356907) Images back to top
ELISA 1: 1,000. Western blot 1: 50 - 1: 100. Immunohistchemistry 1: 10 - 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPT Antibody Target Details MAPT Application Details References for anti-MAPT antibody (ABIN356907) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.|
References for anti-MAPT antibody (ABIN356907)Product Details anti-MAPT Antibody Target Details MAPT Application Details Handling Images back to top
Beck, Rohrer, Campbell, Isaacs, Morrison, Goodall, Warrington, Stevens, Revesz, Holton, Al-Sarraj, King, Scahill, Warren, Fox, Rossor, Collinge, Mead: "A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series." in: Brain : a journal of neurology, Vol. 131, Issue Pt 3, pp. 706-20, 2008
McCulloch, Kay, Factor, Samii, Nutt, Higgins, Griffith, Roberts, Leis, Montimurro, Zabetian, Payami: "Exploring gene-environment interactions in Parkinson's disease." in: Human genetics, Vol. 123, Issue 3, pp. 257-65, 2008
Mateo, Sánchez-Juan, Rodríguez-Rodríguez, Infante, Fernández-Viadero, Peña, Berciano, Combarros: "14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk." in: Dementia and geriatric cognitive disorders, Vol. 25, Issue 4, pp. 317-20, 2008
ImagesProduct Details anti-MAPT Antibody Target Details MAPT Application Details Handling References for anti-MAPT antibody (ABIN356907) back to top