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|Antigen||Microtubule-Associated Protein tau (MAPT) Antibodies|
|Epitope||AA 29-44, N-Term Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MAPT antibody is un-conjugated Alternatives|
Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-MAPT AntibodyTarget Details MAPT Application Details Handling References for anti-MAPT antibody (ABIN3043190) Images
|Purpose||Rabbit IgG polyclonal antibody for Microtubule-associated protein tau(MAPT) detection. Tested with WB in Human,Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Microtubule-associated protein tau(MAPT) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: microtubule-associated protein tau
Protein Name: Microtubule-associated protein tau
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human Tau(29-44aa YTMHQDQEGDTDAGLK), different from the related mouse and rat sequences by three amino acids.|
Target Details MAPTProduct Details anti-MAPT Antibody Application Details Handling References for anti-MAPT antibody (ABIN3043190) Images back to top
|Alternative Name||MAPT (MAPT Antibody Abstract)|
MAPT, Microtubule-associated protein tau, appears to be enriched in axons. The MAPT gene is assigned to chromosome 17 by hybridization of a cDNA clone to flow-sorted and spot-blotted chromosomes and to 17q21 by in situ hybridization, containing 16 exons. The tau proteins are the product of alternative splicingfrom a single gene that in humans is designated MAPT. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons in the central nervous system and are less common elsewhere. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.
Synonyms: AI413597 antibody|AW045860 antibody|DDPAC antibody|Disinhibition dementia parkinsonism amyotrophy complex antibody|FLJ31424 antibody|FTDP 17 antibody|FTDP17 antibody|G Protein beta 1 gamma 2 subunit interacting factor 1 antibody|G protein beta1/gamma2 subunit interacting factor 1 antibody|MAPT antibody|MAPTL antibody|MGC134287 antibody|MGC138549 antibody|MGC156663 antibody|Microtubule associated protein tau antibody|Microtubule associated protein tau isoform 4 antibody|Microtubule associated protein tau, isoform 4 antibody|Microtubule-associated protein tau antibody|MSTD antibody|MTAPT antibody|MTBT 1 antibody|MTBT 2 antibody|MTBT1 antibody|MTBT2 antibody|Neurofibrillary tangle protein antibody|Paired helical filament tau antibody|Paired helical filament-tau antibody|PHF tau antibody|PHF-tau antibody|PPND antibody|pTau antibody|RNPTAU antibody|TAU antibody|TAU_HUMAN antibody|Tauopathy and respiratory failure, included antibody
|Pathways||MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size|
Application DetailsProduct Details anti-MAPT Antibody Target Details MAPT Handling References for anti-MAPT antibody (ABIN3043190) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPT Antibody Target Details MAPT Application Details References for anti-MAPT antibody (ABIN3043190) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
References for anti-MAPT antibody (ABIN3043190)Product Details anti-MAPT Antibody Target Details MAPT Application Details Handling Images back to top
|Product cited in:||
Zhu, Li, Yuan, Li, Tian, Jia, Xiao: "Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway." in: European journal of pharmacology, Vol. 762, pp. 239-46, 2015
Li, Li, Li, Quan, Wang: "Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease." in: Neural regeneration research, Vol. 7, Issue 36, pp. 2860-6, 2014
Tu, Pang, Chen, Zhang, Zhang, Lu, Wang: "Effects of surface charges of graphene oxide on neuronal outgrowth and branching." in: The Analyst, Vol. 139, Issue 1, pp. 105-15, 2013
Tan, Cao, Wang, Lv, Wu, Ma: "Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats." in: Clinical and experimental pharmacology & physiology, Vol. 37, Issue 10, pp. 1010-5, 2010
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