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These results suggest that RSK1 protects P-gp (show ABCB4 Proteins) against ubiquitination by reducing UBE2R1 (show CDC34 Proteins) stability.
Data suggest that UBR5 down-regulates levels of TRAF3 (show TRAF3 Proteins), a key component of Toll (show TLR4 Proteins)-like receptor signaling, via the miRNA pathway; p90RSK is an upstream regulator of UBR5; p90RSK phosphorylates UBR5 as required for translational repression of TRAF3 (show TRAF3 Proteins) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (show TRAF3 Proteins) = TNF receptor-associated factor 3 (show TRAF3 Proteins); p90RSK = 90 kDa ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins))
Data indicate that BTG2 (show BTG2 Proteins), MAP3K11 (show MAP3K11 Proteins), RPS6KA1 and PRDM1 (show PRDM1 Proteins) as putative targets of microRNA miR (show MLXIP Proteins)-125b.
VEGF-A (show VEGFA Proteins) driven Mdm2 (show MDM2 Proteins) phosphorylation on Ser166 is dependent on the ERK1/2/p90RSK signaling pathway in primary human endothelial cells.
The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID (show BID Proteins) may serve as an alternative cancer treatment in NSCLC.
RSK1 binds to EBP50 (show SLC9A3R1 Proteins) at its first PDZ domain, and mitogen activated RSK1 phosphorylates EBP50 (show SLC9A3R1 Proteins) at T156, an event that is crucial for its nuclear localization
Data show that the 90 kDa ribosomal protein S6 (show RPS6 Proteins) kinases RSK1 and RSK2 (show RPS6KA3 Proteins) play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.
RSK1 and 3 but not RSK2 (show RPS6KA3 Proteins) are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer.
PKD2 (show PKD2 Proteins) and RSK1 regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.
Results indicate that the phosphorylation of EphA2 (show EPHA2 Proteins) at Ser (show SIGLEC1 Proteins)-897 is controlled by RSK and the RSK-EphA2 (show EPHA2 Proteins) axis might contribute to cell motility and promote tumour malignant progression.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1 (show PER1 Proteins)(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
Data show that the phosphoinositide-dependent kinase 1 (PDK1 (show PDPK1 Proteins))-p90 (show GPAM Proteins) kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.
IL-6 (show IL6 Proteins) induces the activation of the Stat3 (show STAT3 Proteins) signaling and promotes the downmodulation of the p90RSK/eEF2 (show EEF2 Proteins) and mTOR (show FRAP1 Proteins)/p70S6K (show RPS6KB1 Proteins) axes, while it does not affect the activation of AKT (show AKT1 Proteins).
analysis of p38 (show CRK Proteins)-MK2 (show KCNA2 Proteins)-activated Rsk signaling in toll (show TLR4 Proteins)-like receptor-stimulated dendritic cells
These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK (show EPHB2 Proteins), which for quetiapine occurs via an EGFR (show EGFR Proteins)-linked mechanism, possibly indicating involvement of this system in its action.
hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 (show SLC9A1 Proteins) induces cardiomyocyte apoptosis.
RSK1 Cys223 glutathionylation may contribute to regulate the levels of nitric in the brain.
Our study highlights the importance of the p90RSK/ERK5 (show MAPK7 Proteins) module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation.
Results show increased protein levels of Rsk1 and Rsk2 (show RPS6KA3 Proteins) in the striatum of Huntington disease (show HTT Proteins) mice and and striatal cells transfected with full-length mutant Huntingtin (show HTT Proteins).
Type I keratin (show KRT12 Proteins) 17 (show KRT17 Proteins) protein is phosphorylated on serine 44 by p90 (show GPAM Proteins) ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
90 kDa ribosomal protein S6 kinase 1
, MAP kinase-activated protein kinase 1a
, MAPK-activated protein kinase 1a
, MAPKAP kinase 1a
, S6K-alpha 1
, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
, p90-RSK 1
, ribosomal S6 kinase 1
, ribosomal protein S6 kinase alpha 1
, ribosomal protein S6 kinase alpha-1
, ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1
, MAP kinase-activated protein kinase 1
, MAPK-activated protein kinase 1
, MAPKAP kinase 1
, ribosomal protein S6 kinase 2 alpha
, ribosomal protein S6 kinase II alpha
, S6 protein kinase (Rsk-1)
, S6 kinase II beta
, ribosomal protein S6 kinase 2 beta
, ribosomal protein S6 kinase II beta
, ribosomal protein S6 kinase a, polypeptide 1