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MET Products

(Enkephalin (MET))

Categories

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).

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Featured MET Categories

MET Antibodies

High quality antibodies with extensive validation data.

Recommended MET Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IF (p), IHC (p)
Validations
  • (1)
Cat. No. ABIN734048
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p)
Validations
Cat. No. ABIN734050
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p)
Validations
Cat. No. ABIN734057
Quantity 100 μL
Datasheet Datasheet

Recommended MET ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Various Species
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
Cat. No. ABIN1884688
Quantity 96 tests
Datasheet Datasheet

Latest Publications for our MET products

Brestoff, Kim, Saenz, Stine, Monticelli, Sonnenberg, Thome, Farber, Lutfy, Seale, Artis: "Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity." in: Nature, (2015) (PubMed).

Mosnaim, Maturana, Callaghan, Wolf: "Changes in plasma methionine-enkephalin levels associated with a cluster headache episode." in: American journal of therapeutics, Vol. 20, Issue 5, pp. 463-8, (2014) (PubMed).

Lu, Evans, Hirano, Liu: "Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 1, pp. E168-77, (2014) (PubMed).

Tao, Tao, Chen, Yang, Lu, Sun, Huang, Yu: "Proteinase-activated receptor 1 contributed to up-regulation of enkephalin in keratinocytes of patients with obstructive jaundice." in: Anesthesiology, Vol. 121, Issue 1, pp. 127-39, (2014) (PubMed).

McLeod, Kobayashi, Sen, Baghbaderani, Sadi, Ulalia, Behie, Mendez: "Transplantation of GABAergic cells derived from bioreactor-expanded human neural precursor cells restores motor and cognitive behavioral deficits in a rodent model of Huntington's disease." in: Cell transplantation, Vol. 22, Issue 12, pp. 2237-56, (2014) (PubMed).

Kupchik, Kalivas: "The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: an electrophysiological study." in: Brain structure & function, Vol. 218, Issue 6, pp. 1487-500, (2013) (PubMed).

Riters, Ellis, Angyal, Borkowski, Cordes, Stevenson: "Links between breeding readiness, opioid immunolabeling, and the affective state induced by hearing male courtship song in female European starlings (Sturnus vulgaris)." in: Behavioural brain research, Vol. 247, pp. 117-24, (2013) (PubMed).

Nakamura, Tomida, Yamamoto, Ando, Takamata, Kondo, Kurasawa, Asanuma: "The endogenous opioids related with antinociceptive effects induced by electrical stimulation into the amygdala." in: The open dentistry journal, Vol. 7, pp. 27-35, (2013) (PubMed).

Kelm-Nelson, Stevenson, Cordes, Riters: "Modulation of male song by naloxone in the medial preoptic nucleus." in: Behavioral neuroscience, Vol. 127, Issue 3, pp. 451-7, (2013) (PubMed).

deCampo, Fudge: "Amygdala projections to the lateral bed nucleus of the stria terminalis in the macaque: comparison with ventral striatal afferents." in: The Journal of comparative neurology, Vol. 521, Issue 14, pp. 3191-216, (2013) (PubMed).

Synonyms and alternative names related to MET

proenkephalin (PENK), proenkephalin (Penk), Enk, Penk-rs, Penk1, Penk2

Protein level used designations for MET

  • enkephalin
  • preproenkephalin 2
  • proenkephalin 1
  • proenkephalin 2
  • proenkephalin related sequence
  • proenkephalin-A
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