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Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.
Megalin mediates transepithelial albumin (show ALB Proteins) clearance from the alveolar space of intact rabbit lungs
low-level LPS (show IRF6 Proteins)-mediated TNF-alpha (show TNF Proteins)-ERK1/2 signaling pathway is involved in downregulation of megalin expression in IRPTCs.
patients with OCRL-1 (show OCRL Proteins) mutations or type 1 Dent disease showed abnormally low levels of urinary A-megalin
An Emerging Role for Megalin as a Regulator of Protein Leak in Acute Lung Injury.
Review of LRP2 function. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans.
A novel LRP2 missense variant rs17848169 (N2632D) was found to be associated with lower risk for T2D-ESRD in this population.
we discovered one novel locus (LRP2; most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).
miR (show MLXIP Proteins)-148b directly down-regulates renal megalin expression.
Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules.
The studies suggest that impaired endocytosis of megalin/cubilin (show CUBN Proteins) ligands, hemoglobin (show HBB Proteins) and albumin (show ALB Proteins), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.
VDR (show CYP27B1 Proteins) and MEGALIN gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.
the main role for placental megalin is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin in the cytotrophoblasts.
TTR (show TTR Proteins) neuritogenic activity is mediated by the megalin receptor and is lost in megalin-deficient neurons.
in a bleomycin-based model of acute lung injury, megalin(+/-) animals (the megalin(-/-) variant is lethal due to postnatal respiratory failure) showed a marked increase in intra-alveolar protein and more severe lung injury compared with wild-type littermates
Cell type-specific glycoforms of megalin exist in the proximal tubular cells and modulate ligand absorption capacity.
This study evaluated the role of transcobalamin (TC), the transcobalamin receptor (CD320 (show CD320 Proteins)) , and megalin in various tissues during pregnancy.
miR (show MLXIP Proteins)-148b negatively regulates megalin expression in unilateral ureteral obstruction-induced kidney injury.
study reveals a cross talk between ATR signaling and DPP4 (show DPP4 Proteins) activation in the regulation of megalin and underscores the significance of targeting DPP4 (show DPP4 Proteins) in the prevention of obesity related kidney injury progression.
LRP2 plays a crucial role in cardiovascular development in mice.
Foxg1 (show FOXG1 Proteins)-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia
megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
low density lipoprotein-related protein 2
, low-density lipoprotein receptor-related protein 2
, low density lipoprotein receptor-related protein 2
, low-density lipoprotein receptor-related protein 2-like
, Heymann nephritis antigen homolog
, calcium sensor protein
, glycoprotein 330