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PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA.
the human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs
BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients.
downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells
Data (including data from studies in transgenic mice) suggest that up-regulation of Acot7 expression in clonal beta-cells impairs insulin secretion in response to glucose plus free fatty acids; expression of Acot7 is ubiquitous across tissues but relatively silenced/disallowed in pancreatic beta cells.
ACOT7 may be involved in dietary intake-associated responses in fatty acid metabolism in mesenteric lymph nodes.
ACOT7 counterregulates fatty acid metabolism in neurons and protects against neurotoxicity.
mBACH cDNA encoded a 338-AA pp >95% identical to human and rat homologs. mBACH was distributed throughboth central and peripheral cell body and neurites. Another 50-kDa pp made from mBACH mRNA used different in-frame ATGs as initiation codon.
Acot7 gene is expressed as multiple isoforms in a tissue-specific manner; expression in tissues other than brain and testis is likely to play important roles in fatty acid metabolism.
The structural basis for recruitmment of tandem domains in Acot7 is demonstrated and its role in inflammation presented.
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.
acyl-CoA thioesterase 7
, cytosolic acyl coenzyme A thioester hydrolase
, cytosolic acyl coenzyme A thioester hydrolase-like
, brain acyl-CoA hydrolase
, acyl-CoA thioesterase 2
, acyl-CoA thioesterase, long chain
, brain acyl CoA hydrolase
, long chain acyl-CoA thioester hydrolase
, 50-kDa brain acyl-CoA hydrolase