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|Antigen||Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) Antibodies|
|Reactivity||Human, Rat (Rattus), Mouse (Murine) Alternatives|
|Conjugate||This KCNQ1 antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-KCNQ1 AntibodyTarget Details KCNQ1 Application Details Handling Images
|Specificity||Specific for KCNQ1.|
|Immunogen||A synthetic peptide from the c-terminal region of mouse KCNQ1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in human and rat.|
|Plasmids, Primers & others|
Target Details KCNQ1Product Details anti-KCNQ1 Antibody Application Details Handling Images back to top
|Alternative Name||KCNQ1 (KCNQ1 Antibody Abstract)|
Function: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Tissue specificity: Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cytoplasmic vesicle membrane, Multi-pass membrane protein Also known as: Potassium voltage-gated channel subfamily KQT member 1, Voltage-gated potassium channel subunit Kv7.1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Kcna9.
|Pathways||Negative Regulation of Hormone Secretion, Sensory Perception of Sound|
Application DetailsProduct Details anti-KCNQ1 Antibody Target Details KCNQ1 Handling Images back to top
A dilution of 1 : 200 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
|Restrictions||For Research Use only|
HandlingProduct Details anti-KCNQ1 Antibody Target Details KCNQ1 Application Details Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|
ImagesProduct Details anti-KCNQ1 Antibody Target Details KCNQ1 Application Details Handling back to top