anti-Human CD40 Ligand antibody for Blocking Reagent

Recommended CD40 Ligand Antibody (supplied by: Log in to see )

Antigen
CD40 Ligand (CD40LG) Antibodies
  • CD154
  • cd40l
  • CD40L
  • HIGM1
  • IGM
  • IMD3
  • T-BAM
  • TNFSF5
  • TRAP
  • gp39
  • hCD40L
  • CD40-L
  • Cd40l
  • Ly-62
  • Ly62
  • Tnfsf5
  • CD40 ligand
  • TNF superfamily member 5
  • CD40LG
  • cd40l
  • Cd40lg
Reactivity
Human
512
264
62
33
20
12
8
6
6
5
4
4
3
3
3
2
2
1
1
1
Host
Mouse
311
205
107
70
29
25
3
1
Clonality
Monoclonal
Conjugate
This CD40 Ligand antibody is conjugated to APC
84
65
50
21
14
14
12
12
12
10
9
9
9
9
9
8
8
7
6
5
5
5
5
5
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS)
450
319
157
138
75
71
54
46
38
34
13
11
11
9
9
6
5
5
4
4
2
2
2
1
1
1
1
1
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Catalog No. ABIN2658498
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2657641 BR CyTOF FACS IHC IP WB Alexa Fluor 647 Mouse IgG1 kappa Log in to see 24-31 9
1 ABIN5668046 BR FACS WB Human IgG1, kappa Log in to see hu5c8 (Ruplizumab) 0
1 ABIN5668047 BR FACS WB Rabbit IgG, kappa Log in to see Chimeric 0
1 ABIN5012859 BR CyTOF FACS IHC WB Mouse IgG2b AA 50-261 Log in to see 40804 0
1 ABIN2658499 BR FACS APC Mouse IgG1 kappa Log in to see 24-31 9
1 ABIN5526168 BR FACS Mammalian Cells IgG1 kappa Log in to see hu5c8 0

General

Antigen CD40 Ligand (CD40LG) Antibodies
Reactivity Human
(512), (264), (62), (33), (20), (12), (8), (6), (6), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1)
Host Mouse
(311), (205), (107), (70), (29), (25), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD40 Ligand antibody is conjugated to APC
(84), (65), (50), (21), (14), (14), (12), (12), (12), (10), (9), (9), (9), (9), (9), (8), (8), (7), (6), (5), (5), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Blocking Reagent (BR), Flow Cytometry (FACS)
(450), (319), (157), (138), (75), (71), (54), (46), (38), (34), (13), (11), (11), (9), (9), (6), (5), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 9 references available
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Product Details anti-CD40 Ligand Antibody

Target Details CD40 Ligand Application Details Handling References for anti-CD40 Ligand antibody (ABIN2658498) Images
Cross-Reactivity Cynomolgus, Rhesus Monkey
Purification The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Clone 24-31
Isotype IgG1 kappa
Plasmids, Primers & others

Target Details CD40 Ligand

Product Details anti-CD40 Ligand Antibody Application Details Handling References for anti-CD40 Ligand antibody (ABIN2658498) Images back to top
Antigen
Alternative Name CD154 (CD40LG Antibody Abstract)
Background CD154 (CD40 ligand) is also known as CD40L, gp39, TRAP and T-BAM. CD40 ligand is a 32-39 kD type II transmembrane glycoprotein. It is a member of the TNF superfamily and is expressed on activated T cells. It has been reported to be important for B cell costimulation following binding of its receptor, CD40. Additionally, binding of CD40L to CD40 on B cells promotes the secretion of immunoglobulin and Ig isotype switching. CD40L is also involved in the regulation of cytokine production by T cells.
Pathways NF-kappaB Signaling, Production of Molecular Mediator of Immune Response

Application Details

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Handling References for anti-CD40 Ligand antibody (ABIN2658498) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details References for anti-CD40 Ligand antibody (ABIN2658498) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-CD40 Ligand antibody (ABIN2658498)

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Handling Images back to top
Background publications

Matus-Nicodemos, Vavassori, Castro-Faix, Valentin-Acevedo, Singh, Marcelli, Covey: "Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 2164-71, 2011

Kuchen, Robbins, Sims, Sheng, Phillips, Lipsky, Ettinger: "Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 9, pp. 5886-96, 2007

Nordström, Jendholm, Samuelsson, Forsgren, Riesbeck: "The IgD-binding domain of the Moraxella IgD-binding protein MID (MID962-1200) activates human B cells in the presence of T cell cytokines." in: Journal of leukocyte biology, Vol. 79, Issue 2, pp. 319-29, 2006

Najafian, Khoury: "T cell costimulatory pathways: blockade for autoimmunity." in: Expert opinion on biological therapy, Vol. 3, Issue 2, pp. 227-36, 2003

Stuart, Racke: "Targeting T cell costimulation in autoimmune disease." in: Expert opinion on therapeutic targets, Vol. 6, Issue 3, pp. 275-89, 2002

Rushworth, Bravery, Hall, Natt, Parsons, Weiler, Häner, Thompson: "Inhibition of CD40-mediated endothelial cell activation with antisense oligonucleotides." in: Transplantation, Vol. 73, Issue 4, pp. 635-42, 2002

Brams, Black, Padlan, Hariharan, Leonard, Chambers-Slater, Noelle, Newman: "A humanized anti-human CD154 monoclonal antibody blocks CD154-CD40 mediated human B cell activation." in: International immunopharmacology, Vol. 1, Issue 2, pp. 277-94, 2001

Berner, Wolf, Hummel, Müller, Reuss-Borst: "Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 59, Issue 3, pp. 190-5, 2000

Ford, Barnhart, Shone, Covey: "Regulation of CD154 (CD40 ligand) mRNA stability during T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 7, pp. 4037-44, 1999

Images

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Handling References for anti-CD40 Ligand antibody (ABIN2658498) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-CD40 Ligand (CD40LG) antibody (APC) (ABIN2658498) anti-CD40 Ligand (CD40LG) antibody (APC)