anti-Human CD40 Ligand antibody for Blocking Reagent

Recommended CD40 Ligand Antibody (supplied by: Log in to see )

Antigen
CD40 Ligand (CD40LG) Antibodies
  • CD154
  • cd40l
  • CD40L
  • HIGM1
  • IGM
  • IMD3
  • T-BAM
  • TNFSF5
  • TRAP
  • gp39
  • hCD40L
  • CD40-L
  • Cd40l
  • Ly-62
  • Ly62
  • Tnfsf5
  • CD40 ligand
  • TNF superfamily member 5
  • CD40LG
  • cd40l
  • Cd40lg
Reactivity
Human
452
197
63
33
20
12
8
5
4
4
3
3
3
3
2
2
2
1
1
1
Host
Human
254
208
87
31
23
17
2
1
Antibody Type
Recombinant Antibody
Clonality
Monoclonal
Conjugate
This CD40 Ligand antibody is un-conjugated
76
54
42
15
7
7
7
6
6
5
5
4
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)
345
296
151
107
72
43
41
36
34
23
13
11
9
9
8
6
5
4
3
3
2
2
2
1
1
1
1
1
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Catalog No. ABIN5668046
$ 427.14
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
16.252602 ABIN5668047 BR FACS WB Rabbit IgG, kappa Log in to see Chimeric 0
4 ABIN2658498 BR FACS APC Mouse IgG1 kappa Log in to see 24-31 9
4 ABIN2657641 BR CyTOF FACS IHC IP WB Alexa Fluor 647 Mouse IgG1 kappa Log in to see 24-31 9
4 ABIN5012859 BR CyTOF FACS IHC WB Mouse IgG2b AA 50-261 Log in to see 40804 0
1 ABIN2658499 BR FACS APC Mouse IgG1 kappa Log in to see 24-31 9
1 ABIN5526168 BR FACS Mammalian Cells IgG1 kappa Log in to see hu5c8 0

General

Antigen CD40 Ligand (CD40LG) Antibodies
Reactivity Human
(452), (197), (63), (33), (20), (12), (8), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Host Human
(254), (208), (87), (31), (23), (17), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD40 Ligand antibody is un-conjugated
(76), (54), (42), (15), (7), (7), (7), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)
(345), (296), (151), (107), (72), (43), (41), (36), (34), (23), (13), (11), (9), (9), (8), (6), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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Product Details anti-CD40 Ligand Antibody

Target Details CD40 Ligand Application Details Handling Images
Specificity The antibody binds to CD40L with an IC50 of 0.845 μg/mL.
Characteristics Human IgG1 based on the original Human IgG1
Purification Purified antibody.
Purity > 98 % as determined by SDS-PAGE
Endotoxin Level Endotoxin is < 1.0 EU/mg as determined by the LAL method
Immunogen Human CD40L
Clone Hu5c8 (Ruplizumab)
Isotype IgG1, kappa
Plasmids, Primers & others

Target Details CD40 Ligand

Product Details anti-CD40 Ligand Antibody Application Details Handling Images back to top
Antigen
Alternative Name CD40L (CD40LG Antibody Abstract)
Background CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, CD154, tumour necrosis factor related activation protein, TRAP
Pathways NF-kappaB Signaling, Production of Molecular Mediator of Immune Response

Application Details

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Handling Images back to top
Application Notes The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531? ±?155 hours.
Comment

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Restrictions For Research Use only

Handling

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Images back to top
Buffer PBS with 0.02 % Proclin 300.
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Images

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-CD40 Ligand (CD40LG) antibody (ABIN5668046) Western Blot using anti-OX40L antibody Rat spleen (lane 1), rat muscle (lane 2), rat...