anti-Human Insulin antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended Insulin Antibody (supplied by: Log in to see )

Antigen
Insulin (INS) Antibodies
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Reactivity
Human, Rabbit, Rat (Rattus)
948
465
364
348
237
190
45
11
9
8
7
7
6
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Host
Mouse
779
201
49
9
4
2
1
Clonality
Monoclonal
Conjugate
This Insulin antibody is un-conjugated
52
40
36
21
20
20
19
15
15
14
13
13
13
13
13
13
13
10
9
9
7
7
7
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
458
352
269
266
254
232
174
111
106
66
64
35
25
23
21
7
5
4
4
4
4
3
2
2
2
1
1
1
1
1
1
Options
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Catalog No. ABIN3043651
$ 280.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
17.575203 ABIN94408 Func ICC IHC (p) RIA ELISA Mouse IgG1 Log in to see IN-05 1
16.075203 ABIN1027301 IHC (p) Mouse IgG1 kappa Log in to see INS05 0
16.075203 ABIN1027302 IHC (p) Mouse IgG1 kappa Log in to see INS05 0
15.364971 ABIN4326017 IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 2
13.075204 ABIN966408 IHC (fp) IHC (fro) IHC (p) Guinea Pig Log in to see Polyclonal 0
13.075204 ABIN966407 IHC (fp) IHC (fro) IHC (p) Guinea Pig Log in to see Polyclonal 0
13.075204 ABIN2749217 Func ICC IHC (p) RIA ELISA Mouse IgG1 Log in to see IN-05 0
13.075204 ABIN2144386 IHC (p) Mouse IgG1 Log in to see ISL-8J 0
13.075204 ABIN5680095 IHC (p) Rabbit Log in to see Polyclonal 0
13.075204 ABIN1689517 IHC (p) Mouse IgG1 Log in to see ISL-8J 0
11.426565 ABIN337134 ELISA IHC IHC (p) HRP Mouse IgG1, kappa Log in to see 8E2 0
11.426565 ABIN214027 ELISA IHC IHC (p) WB Mouse IgG1, kappa Log in to see 2D11-H5 0
11.426565 ABIN316680 EIA IHC (p) Mouse IgG1 Log in to see 2D11 0
11.426565 ABIN396953 IHC IHC (p) Mouse IgG1, kappa Log in to see 0
11.426565 ABIN461989 ELISA IHC IHC (p) Mouse IgG1 Log in to see 0
11.426565 ABIN337249 FACS ICC IF IHC IHC (p) Rabbit IgG Log in to see Polyclonal 0
10 ABIN391429 FACS IF IHC (p) WB Rabbit Ig Fraction AA 35-64, Center Log in to see Polyclonal 0
10 ABIN724265 IF (p) IHC (p) Rabbit IgG AA 45-95 Log in to see Polyclonal 0
10 ABIN5530710 IHC (p) WB Rabbit Ig Fraction AA 21-52, N-Term Log in to see Polyclonal 0
8.426565 ABIN2610290 ELISA IHC IHC (p) Mouse IgG1 Log in to see 0

General

Antigen Insulin (INS) Antibodies
Reactivity Human, Rabbit, Rat (Rattus)
(948), (465), (364), (348), (237), (190), (45), (11), (9), (8), (7), (7), (6), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(779), (201), (49), (9), (4), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Insulin antibody is un-conjugated
(52), (40), (36), (21), (20), (20), (19), (15), (15), (14), (13), (13), (13), (13), (13), (13), (13), (10), (9), (9), (7), (7), (7), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(458), (352), (269), (266), (254), (232), (174), (111), (106), (66), (64), (35), (25), (23), (21), (7), (5), (4), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 20 references available
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Product Details anti-Insulin Antibody

Target Details Insulin Application Details Handling References for anti-Insulin antibody (ABIN3043651) Images
Purpose Mouse IgG monoclonal antibody for Insulin, insulin (INS) detection. Tested with IHC-P in Human,rabbit,rat. No cross reactivity with other proteins.
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Mouse IgG monoclonal antibody for Insulin, insulin (INS) detection. Tested with IHC-P in Human,rabbit,rat.
Gene Name: insulin
Protein Name: Insulin
Purification Ascites
Immunogen Human insulin.
Clone K36AC10
Isotype IgG1
Plasmids, Primers & others

Target Details Insulin

Product Details anti-Insulin Antibody Application Details Handling References for anti-Insulin antibody (ABIN3043651) Images back to top
Antigen
Alternative Name INS (INS Antibody Abstract)
Background Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns, exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al.(1981) and Harper and Saunders(1981) assigned the insulin gene to 11p15.5 by in situ hybridization.

Synonyms: PROINSULIN|ILPR|IRDN|IDDM2|MODY10|Insulin2|Ins-2
Gene ID 3630, 16334, 24509
UniProt P01308, P01326, P01323
Pathways NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation

Application Details

Product Details anti-Insulin Antibody Target Details Insulin Handling References for anti-Insulin antibody (ABIN3043651) Images back to top
Application Notes IHC-P: Concentration: 0.4-1 μg/mL, Species: Human, rabbit, rat
Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by ABIN921230 in IHC(P).

Restrictions For Research Use only

Handling

Product Details anti-Insulin Antibody Target Details Insulin Application Details References for anti-Insulin antibody (ABIN3043651) Images back to top
Format Lyophilized
Reconstitution Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.
Concentration 100 μg/mL
Buffer Mouse ascites fluid, 1.2 % sodium acetate, 2 mg BSA, with 0.01 mg Sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-Insulin antibody (ABIN3043651)

Product Details anti-Insulin Antibody Target Details Insulin Application Details Handling Images back to top
Product cited in:

Liu, Raynal, Bailbé, Gausseres, Carbonne, Autier, Movassat, Kergoat, Portha: "Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity." in: Biochimica et biophysica acta, Vol. 1852, Issue 5, pp. 980-91, 2015

Liu, Gu, Zhao, An, Yang: "Glypican 4 may be involved in the adipose tissue redistribution in high-fat feeding C57BL/6J mice with peroxisome proliferators-activated receptor ? agonist rosiglitazone treatment." in: Experimental and therapeutic medicine, Vol. 8, Issue 6, pp. 1813-1818, 2014

Xu, Dong, Huang, Li, Qin, Ren, Guo, Chen, Huang: "Decreased osteoclastogenesis, osteoblastogenesis and low bone mass in a mouse model of type 2 diabetes." in: Molecular medicine reports, Vol. 10, Issue 4, pp. 1935-41, 2014

Adise, Saliu, Maldonado, Khatri, Cardoso, Rodríguez-Contreras: "Effect of maternal care on hearing onset induced by developmental changes in the auditory periphery." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 13, pp. 4528-33, 2014

Ding, Zhu, Yin, Liu, Zhang, Bernier, Zhao: "Pyrrolidine dithiocarbamate protects pancreatic ?-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats." in: Acta biochimica et biophysica Sinica, Vol. 46, Issue 7, pp. 582-9, 2014

Chen, Yang, He, Song, Liu: "Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis." in: Neural regeneration research, Vol. 8, Issue 19, pp. 1756-64, 2014

Zhang, Ye, Wang, Gao, Tan, Zhuo, Liu, Xia, Yang, Li: "Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats." in: BioMed research international, Vol. 2013, pp. 526367, 2013

Zhou, Zhou, Zeng: "Experimental diabetes treated with trigonelline: effect on ? cell and pancreatic oxidative parameters." in: Fundamental & clinical pharmacology, Vol. 27, Issue 3, pp. 279-87, 2013

Hu, Yuan, Li, Huang, Mao, Zhang, Lin, Sun, Zhong, Tang, Lu: "Anti-Diabetic Activities of Jiaotaiwan in db/db Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2013, pp. 180721, 2013

Gao, Liu, Liu, Chen, Li, Lei, Sun, Li, Liu, Shen: "A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice." in: Journal of ethnopharmacology, Vol. 151, Issue 1, pp. 675-85, 2013

Wang, Ni, Xu, Liang, Du, Gu: "Effects of long-term high-fat/high-energy and high-protein diets on insulin and ghrelin expression in developing rats." in: Endocrine research, Vol. 37, Issue 3, pp. 97-109, 2012

Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: "Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct." in: Lymphology, Vol. 44, Issue 1, pp. 21-8, 2011

Su, Meng, Sun, Liu, Su: "Intramuscular injection of soluble receptor for advanced glycation endproducts expression vector prevents the development of streptozotocin-induced diabetes mellitus in rats on high fat diet." in: Journal of diabetes, Vol. 3, Issue 4, pp. 309-16, 2011

Xu, Ke, Liang, Wang, Pei, Du: "PEG-rhGH therapy for small for gestational age rats and effects on their metabolic parameters." in: Hormone research in pædiatrics, Vol. 76, Issue 1, pp. 35-43, 2011

Zhang, Jin, Hu, Yu, Li, Ding, Kang, Wang: "Protective response against type 1 diabetes in nonobese diabetic mice after coimmunization with insulin and DNA encoding proinsulin." in: Human gene therapy, Vol. 21, Issue 2, pp. 171-8, 2010

Shen, Liu, Hou, Yang, Wu, Zhang, Li, Che, Lu, Zhang, Liu, Yao: "NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 8, pp. 1371-81, 2010

Chen, Yang, Zheng, Hu, Kong, Zhang: "Effect of catch-up growth after food restriction on the entero-insular axis in rats." in: Nutrition & metabolism, Vol. 7, pp. 45, 2010

Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: "Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats." in: Experimental biology and medicine (Maywood, N.J.), Vol. 234, Issue 5, pp. 595-603, 2009

Liang, Yin, Zhang, Zhang, Zeng, Wang, Jiang, Yuan, Wang, Li: "Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance." in: Endocrinology, Vol. 149, Issue 6, pp. 2943-51, 2008

Lu, Gu, Xu, Liu, Xie, Song: "Adult islets cultured in collagen gel transdifferentiate into duct-like cells." in: World journal of gastroenterology, Vol. 11, Issue 22, pp. 3426-30, 2005

Images

Product Details anti-Insulin Antibody Target Details Insulin Application Details Handling References for anti-Insulin antibody (ABIN3043651) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Insulin (INS) antibody (ABIN3043651) Anti-Insulin antibody (monoclonal), IHC(P) IHC(P): Rat Pancreas Tissue
Immunohistochemistry (IHC) image for anti-Insulin (INS) antibody (ABIN3043651) Anti-Insulin antibody (monoclonal), IHC(P) IHC(P): Rat Pancreas Tissue