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In the present study, we identified that the adaptor protein Numb (show NUMB Proteins), which is demonstrated to be a novel binding partner of NEDD4-1, plays important roles in controlling PTEN ubiquitination through regulating NEDD4-1 activity and the association between PTEN and NEDD4-1.
NEDD4 is an autophagic E3 ubiquitin ligase (show MUL1 Proteins) that ubiquitylates SQSTM1 (show SQSTM1 Proteins), facilitating SQSTM1 (show SQSTM1 Proteins)-mediated inclusion body autophagy.
NEDD4 is largely involved in epithelial-mesenchymal transition features and chemoresistance of nasopharyngeal carcinoma cancer cells.
NEDD4 ligase regulates RTP801 (show DDIT4 Proteins) and is sensitive to Parkinson disease-associated oxidative stress
Two additional regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes: the E3 ubiquitin ligases NEDD4 and MARCH8, are reported.
SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity.
Our results reveal a novel mechanism of upregulation of NEDD4 expression in pancreatic adenocarcinoma
Describe an autoinhibitory mechanism for NEDD4-1 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.
NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1 (show SERTAD1 Proteins). Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 (show SERTAD1 Proteins) are identified by NMR titration experiments.
expression or dysfunction of Nedd4 E3 ligase could be involved in vascular calcification of VSMCs by activating bone-forming signals during atherosclerosis progression
Nedd4-1 is required for efficient internalization of major growth factor receptors involved in liver regeneration and their downstream mitogenic signaling.
NPM1 (show GJA1 Proteins)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Proteins) activation cascade.
these results suggest that Nedd4 suppresses colonic WNT (show WNT2 Proteins) signaling and tumor growth, at least in part, by suppressing the transcription factors LEF1 (show LEF1 Proteins) and YY1 (show YY1 Proteins).
Findings indicate that reducing Nedd4 protein by 50% significantly impairs long-term potentiation and long-term memory thereby demonstrating an important role for Nedd4 in these processes.
Upregulation of long non-coding RNA PAPAS (show PSTPIP1 Proteins) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2 (show SUV420H2 Proteins).
we propose that Nedd4 functions as a novel Pax7 (show PAX7 Proteins) regulator, which activity is temporally and spatially controlled to modulate the Pax7 (show PAX7 Proteins) protein levels and therefore satellite cell fate.
PDLIM7 (show PDLIM7 Proteins) is a bona fide skeletal muscle substrate of Nedd4-1.
show that absence of Nedd4 in pre-osteoblasts results in decreased cell proliferation and altered osteogenic differentiation
Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 (show IRS2 Proteins) in vivo.
miR-1-mediated regulation of Nedd4/Nedd4L (show NEDD4L Proteins) expression may serve to broadly modulate the trafficking or degradation of Nedd4/Nedd4L (show NEDD4L Proteins) substrates in the heart
Nedd4Lo destabilizes Amph (show AMPH Proteins) in muscles, leading to impaired T-tubule formation and muscle function.
NEDD4 controls the Hippo pathway leading to coordinated cell proliferation and apoptosis
data in two evolutionarily distant model organisms strongly suggest that Nedd4 is a modifier of alpha-synuclein pathobiology and thus a potential target for neuroprotective therapies
Nedd4, another E3 ubiquitin ligase that may have a role in PD, is functionally related to Sep4 and could be involved in regulating Sep4 subcellular localization/trafficking.
splice isoforms of the same dNedd4 gene can lead to opposite effects on neuromuscular synaptogenesis
Nedd4 regulates endocytosis of notch (show NOTCH1 Proteins) and suppresses its ligand-independent activation.
These studies provide insights into the specific regulation of dNedd4-mediated ubiquitination of Comm and subsequent internalization of Comm or the Comm/Roundabout (show ROBO1 Proteins) complex, critical for CNS and muscle development.
dNedd4 and ubiquitination are required for Commissureless endocytosis and proper neuromuscular synaptogenesis.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).
E3 ubiquitin-protein ligase NEDD4
, cell proliferation-inducing gene 53 protein
, neural precursor cell expressed developmentally down-regulated protein 4
, receptor-potentiating factor 1
, neural precursor cell expressed, developmentally down-regulated gene 4
, neural precursor cell expressed, developmentally down-regulated gene 4a
, neural precursor cell expressed, developmentally down-regulted gene 4
, neural precursor cell expressed, developmentally down-regulated 4
, ubiquitin-protein ligase Nedd4
, E3 ubiquitin-protein ligase NEDD4-like
, e3 ubiquitin-protein ligase NEDD4-like
, neural precursor cell expressed, developmentally down-regulated gene 4A