Browse our anti-Jumonji Domain Containing 1C (JMJD1C) Antibodies

Human Jumonji Domain Containing 1C (JMJD1C) interaction partners

1. JMJD1C is the autosomal gene where variants have been demonstrated to be associated with Testosterone (one of Cardiovascular disease risk factors) at genome-wide significance.

2. Study provides evidence that SNPs of JMJD1C and KCNQ1 are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.

3. JMJD1C is one of the target genes of hsa-miR-590- 3p.

4. Our findings indicate that mutations in JMJD1C contribute to the development of Rett syndrome and intellectual disability.

5. genetic variants in the androgen-related genes CYP17A1 and JMJD1C might be associated with risk of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC).

6. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome.

7. JMJD1C is directly recruited by RUNX1-RUNX1T1 to its target genes and regulates their expression by maintaining low H3K9 dimethyl (H3K9me2) levels

8. Depletion of JMJD1C impairs expansion and colony formation of leukemic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM.

9. JMJD1C represses neural differentiation of hESCs at least partially by epigenetically sustaining miR-302 expression

10. JMJD1C regulates the RAP80-BRCA1 branch of this DNA-damage response (DDR) pathway.

11. No evidence for JMJD1C histone demethylase activity towards H3K9.

12. TRIP8 gene codes for a protein predicted to be a transcriptional regulator associated with nuclear thyroid hormone receptors. Positional candidate gene for autism.

13. the discovery of a new Receptors, Androgen coactivator which belongs to the JmjC containing enzyme family as a novel variant of JMJD1C

14. Human JMJD1C variant 2 with TRI8H1, TRI8H2, and JmjC domains showed 85.7% total-amino-acid identity with mouse Jmjd1c.

Mouse (Murine) Jumonji Domain Containing 1C (JMJD1C) interaction partners

1. data suggest that Jmjd1c may participate in mitotic clonal expansion and the activation of the adipogenic transcription program during the induction phase of adipocyte differentiation in 3T3-L1 cells.

2. JMJD1C ensures efficient generation and maintenance of induced pluripotent stem cells, at least partially through controlling the expression of microRNAs.

3. These results indicate that JMJD1C has multiple functions during spermatogenesis through interactions with different partners during the spermatogenic stages

4. JMJD1C is an important mediator of MLL-AF9- and HOXA9-driven leukemia stem cell function that is largely dispensable for hematopoietic stem cells function.

5. Data suggest that Jmjd1c is most abundantly expressed in testis in undifferentiated spermatogonia; testes of mutant mice deficient in Jmjd1c frequently contain abnormal seminiferous tubules lacking developmentally immature germ cells.

6. Depletion of Jmjd1c impairs growth and colony formation of MLL-AF9 cells in vitro as well as establishment of leukemia after transplantation.

Cow (Bovine) Jumonji Domain Containing 1C (JMJD1C) interaction partners

1. These data suggest that JMJD1C plays a key role in the normal development of early bovine embryos