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Study provides evidence that SNPs of JMJD1C and KCNQ1 (show KCNQ1 Antibodies) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 (show CDKAL1 Antibodies) may not be associated with T2D onset over the age of 40.
JMJD1C is one of the target genes of hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-590- 3p.
Our findings indicate that mutations in JMJD1C contribute to the development of Rett syndrome and intellectual disability.
genetic variants in the androgen-related genes CYP17A1 (show CYP17A1 Antibodies) and JMJD1C might be associated with risk of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC (show CYLD Antibodies)).
Histone modifier genes (JMJD1C, RREB1 (show RREB1 Antibodies), MINA (show MINA Antibodies), KDM7A (show JHDM1D Antibodies)) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome.
JMJD1C is directly recruited by RUNX1 (show RUNX1 Antibodies)-RUNX1T1 (show RUNX1T1 Antibodies) to its target genes and regulates their expression by maintaining low H3K9 dimethyl (H3K9me2) levels
Depletion of JMJD1C impairs expansion and colony formation of (show MLL Antibodies)leuk (show MLLT3 Antibodies)emic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM.
JMJD1C represses neural differentiation of hESCs at least partially by epigenetically sustaining miR (show MLXIP Antibodies)-302 expression
JMJD1C regulates the RAP80 (show UIMC1 Antibodies)-BRCA1 branch of this DNA-damage response (DDR (show DDR1 Antibodies)) pathway.
No evidence for JMJD1C histone demethylase (show MBD2 Antibodies) activity towards H3K9.
JMJD1C ensures efficient generation and maintenance of induced pluripotent stem cells, at least partially through controlling the expression of microRNAs.
These results indicate that JMJD1C has multiple functions during spermatogenesis through interactions with different partners during the spermatogenic stages
JMJD1C is an important mediator of MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)- and HOXA9 (show HOXA9 Antibodies)-driven leukemia stem cell function that is largely dispensable for hematopoietic stem cells function.
Data suggest that Jmjd1c is most abundantly expressed in testis (show XKR3 Antibodies) in undifferentiated spermatogonia; testes of mutant mice deficient in Jmjd1c frequently contain abnormal seminiferous tubules lacking developmentally immature germ cells.
Depletion of Jmjd1c impairs growth and colony formation of MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) cells in vitro as well as establishment of leukemia after transplantation.
These data suggest that JMJD1C plays a key role in the normal development of early bovine embryos
Implicated in the defense of plants against pathogens.
TR-interacting protein 8
, jumonji domain-containing protein 1C
, probable JmjC domain-containing histone demethylation protein 2C
, thyroid hormone receptor interactor 8
, thyroid receptor interacting protein 8
, thyroid receptor-interacting protein 8
, jumonji domain containing 1C
, probable JmjC domain-containing histone demethylation protein 2C-like