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Human NR1H3 Protein expressed in HEK-293 Cells - ABIN2727545
Tian, Goldstein, Brown: Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex. in Proceedings of the National Academy of Sciences of the United States of America 2016
Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.
PBMCs from healthy persons were predisposed to the MPhi2 differentiation phenotype, which exhibits elevated cholesterol uptake and anti-inflammatory properties. LXRalpha over-expression polarizes macrophages towards the anti-inflammatory MPhi2 phenotype.
LXR gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 levels.
In conclusion, the present study demonstrated that activation of LXRalpha-ABCA1 axis with a synthetic LXR agonist TO90 exerted a potent protective effect against Abeta induced senescent and inflammatory responses in retinal pigment epithelial cells, suggesting that LXR agonists may be promising therapeutic agents for treating age-related macular degeneration.
AMPK (show PRKAA1 Proteins) activates LXRalpha and ABCA1 (show ABCA1 Proteins) expression in human macrophages
PPARalpha (show PPARA Proteins) and LXRalpha may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis
results indicated that LXRalpha plays a specific and important role in activation of TH by regulating D1, and that LXRalpha binds to and regulates the hDIO1 promoter, competing with TRbeta (show TXNRD2 Proteins) on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (show NR1H2 Proteins) (LXRbeta (show NR1H2 Proteins)) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (show NFKB1 Proteins)) activation.
FXR (show NR1H4 Proteins) signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction.
the activation of LXRs protected rd1 (show PDE6B Proteins) mouse retina and rescued visual function by suppressing the immune inflammation mediated by JAK3 (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway. LXRs agonist might become new therapeutic agents for RP.
The LXR agonist TO901317 had potent antioxidant, anti-inflammatory, and antiapoptotic effects against PQ-induced Acute Lung Injury
the anti-inflammatory effect of Saikosaponin a is associated with activating LXRalpha dependent cholesterol efflux pathway which result in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 (show TLR4 Proteins) to lipid rafts, thereby attenuating LPS (show TLR4 Proteins) mediated inflammatory response
The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis.
the agonists inhibited the priming of inflammasome activation. In vivo data also showed that LXRs agonist prevented NLRP3 (show NLRP3 Proteins)-dependent peritonitis. In conclusion, LXRs agonists are identified to potently suppress NLRP3 (show NLRP3 Proteins) inflammasome and the regulation of LXRs signaling is a potential therapeutic for inflammasome-driven diseases.
LXR activation impairs adipose expansion by increasing adipocyte apoptosis, lipolysis and antagonising PPARgamma (show PPARG Proteins)-mediated transcriptional activity, which contributes to decreased insulin (show INS Proteins) sensitivity in whole body.
The present study indicates a requirement for C/EBPbeta (show CEBPB Proteins) in the insulin (show INS Proteins)-mediated induction of SREBP-1c (show SREBF1 Proteins) mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors.
The deletion of Srebf-2 (show SREBF2 Proteins) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR activity and SREBP-1c (show SREBF1 Proteins) expression.
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD (show SCD Proteins)), Fatty acid synthase (FASN (show FASN Proteins)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.
Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.
Allele A of the exon5-A201C in NR1H3 promotes a reduction in backfat thicknes.NR1H3 plays role in lipid deposition.
discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB (show NR1H2 Proteins) Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
nuclear receptor subfamily 1, group H, member 3
, oxysterols receptor LXR-alpha-like
, liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha
, LXR alpha
, liver X receptor alpha
, ubiquitously-expressed nuclear receptor 1
, nuclear orphan receptor LXR-alpha
, nuclear receptor subfamily 1 group H member 3
, liver X receptor
, nuclear oxysterol receptor LxR-alpha