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We demonstrated that small interfering RNA (siRNA)-mediated knockdown of PRR (show PVRL1 Proteins), Nox2 (show CYBB Proteins) and Nox4 (show NOX4 Proteins) significantly reduced the HG-induced stimulation of VEGF (show VEGFA Proteins). On the other hand, Nox4 (show NOX4 Proteins) overexpression significantly potentiated PRR (show PVRL1 Proteins)-induced stimulation of VEGF (show VEGFA Proteins) under hyperglycemia in ARPE-19 cells.
The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma.
High endogenous pregnane X receptor (PXR) level is associated with poor sorafenib therapy outcome.
A total of six studies with 4248 cases and 3853 controls were included in this meta-analysis. Three PXR gene polymorphisms were evaluated: rs1523127, rs2276707, and rs6785049. Our analyses of rs1523127, rs2276707, and rs6785049 suggested that PXR gene polymorphism had no obvious influence on the risk of inflammatory bowel disease in Caucasians.
genotypes and haplotypes of PXR rs3814057, rs3814058 and rs6785049 have impact on the major adverse cardiovascular events in clopidogrel treated patients after percutaneous coronary intervention
replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation
NR1I2 has a role in promoting stem cell-mediated colon cancer relapse
Dual ligands of CAR/PXR show distinct gene regulation patterns by regulating cross-talk between CAR and PXR.
High PXR expression is associated with multidrug resistance in breast cancer.
PXR, CYP3A4 (show CYP3A4 Proteins), and VIL1 (show VIL1 Proteins) expression was decreased only in the actively inflamed small intestinal tissue in children with Crohn's disease.
The regulatory effect of IFN-gamma (show IFNG Proteins) on CYP3A29 expression is mediated via PXR.
Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
In conclusion, PXR and FXR (show NR1H4 Proteins) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (show NR1H4 Proteins) transactivation at in vivo expression levels.
the PXR gene revealed multiple splice variants in the ligand-binding domain
Results demonstrate that PXR acts as a rheostat in fine tuning the balance of innate inflammatory pathways through TLR4 (show TLR4 Proteins) to ensure protective immunity.
Data suggest that regulation of SXR expression is involved in nephrosis induced by environmental poisons; here, nephrosis caused by atrazine herbicide poisoning can be mitigated by supplementation with antioxidant lycopene; in the kidney, mechanisms involved include modulation of SXR expression and of SXR transport to the nucleus.
FXR (show NR1H4 Proteins) signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction.
Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.
The present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands.
FGF21 (show FGF21 Proteins)-PXR signaling pathway may be involved in decreased hepatic CYP3A4 (show CYP3A4 Proteins) metabolic activity in Nonalcoholic fatty liver disease.
Pregnenolone 16alpha-carbonitrile has immunosuppressive activity independent of PXR activation to protect mice from immune-mediated liver injury induced by Con (show KITLG Proteins) A.
carcinogens might trigger PXR in epidermal cells, particularly in Langerhans cells, leading to DNA damage
PXR activation stimulates EGF (show EGF Proteins)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Proteins) from accelerating cell-cycle progression.
The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.
Selected zebrafish CYP1 (show PPIA Proteins), CYP2 and CYP3 genes appear to be under the regulation of both pregnane X receptor and aryl hydrocarbon receptor (show AHR Proteins) 2.
CYP3A65 and PXR may be involved in the metabolization and detoxification of microcystins in zebrafish, which may be regulated by dre (show SUFUH Proteins)-miR (show MYLIP Proteins)-27b.
similar pattern of mRNA expression of PXR, cytochrome P4503A and multiple drug resistance 1 genes found in fish treated with different PXR inducers suggests that the intrinsic association between these three genes is conserved in zebrafish
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
nuclear receptor subfamily 1 group I member 2
, orphan nuclear receptor PAR1
, orphan nuclear receptor PXR
, pregnane X nuclear receptor variant 2
, pregnane X receptor
, steroid and xenobiotic receptor
, Pregnane X receptor
, nuclear receptor subfamily 1, group 1, member 2
, pregnane X receptor (nuclear receptor sub family 1, group I, member 2)
, nuclear receptor subfamily 1 group I member 2 S homeolog
, nuclear receptor subfamily 1, group I, member 2
, orphan nuclear receptor BXR-beta