NR1I2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2727546

Product Details

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NR1I2 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human NR1I2 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Alternative Name: Nr1i2 (NR1I2 Products)

Synonyms: BXR Protein, ONR1 Protein, PAR Protein, PAR1 Protein, PAR2 Protein, PARq Protein, PRR Protein, PXR Protein, SAR Protein, SXR Protein, PXR.1 Protein, PXR.2 Protein, PXR1 Protein, mPXR Protein, bxr Protein, nr1i2 Protein, onr1 Protein, xonr1 Protein, nuclear receptor subfamily 1 group I member 2 Protein, nuclear receptor subfamily 1, group I, member 2 Protein, nuclear receptor subfamily 1 group I member 2 S homeolog Protein, NR1I2 Protein, Nr1i2 Protein, nr1i2.S Protein, nr1i2 Protein

Background: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Molecular Weight: 49.6 kDa

NCBI Accession: NP_003880

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway