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anti-Human RORA Antibodies:
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Human Polyclonal RORA Primary Antibody for ICC, IF - ABIN4350938
Benderdour, Fahmi, Beaudet, Fernandes, Shi: Nuclear receptor retinoid-related orphan receptor α1 modulates the metabolic activity of human osteoblasts. in Journal of cellular biochemistry 2011
Show all 2 Pubmed References
Cow (Bovine) Polyclonal RORA Primary Antibody for WB - ABIN2776008
Tordjman, Leroyer, Chauvet, Quette, Chauvet, Tomkiewicz, Chapron, Barouki, Forest, Aggerbeck, Antoine: Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione. in The Journal of biological chemistry 2007
three copy-number variant deletions (two de novo and one dominantly inherited in three generations), one de novo disrupting duplication, and nine de novo point mutations (three truncating, one canonical splice site, and five missense mutations) involving RORA, are reported.
We have identified RORalpha as a regulator of Treg genes responsible for suppressing allergic skin inflammation and also documented higher expression of RORalpha in skin-resident Tregs than in peripheral blood circulating Tregs in humans, suggesting that RORalpha and the TL1A-DR3 circuit could be therapeutically targeted in atopic dermatitis.
RORA downregulation may be a potential indicator of positive response to interferon beta treatment of multiple sclerosis patients
In the present study we have detected an association between rs4774388 genotype and breast cancer risk in a population of Iranian breast cancer patients.
rs4774388-TT genotype was significantly higher in patients compared with controls and was associated with autism spectrum disorder risk in dominant inheritance model
human melanoma development and aggressiveness is associated with decreased expression of RORalpha and RORgamma, suggesting that RORs could be important in melanoma progression and host responses against the tumor
CYP11A1- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
The expression RORalpha is significantly elevated under hypoxic conditions in keratinocytes in an HIF-1alpha dependent manner.
RORgammat and RORalpha have overlapping roles in human Th17 cell differentiation through regulation of a defined common set of Th17 genes
Retinoid-related orphan receptor alpha-regulated development of the mouse cerebellum has a distinct critical period for (1) lengthening Purkinje cell (PC) primary dendrite stems and the eventual increase in the thickness of the molecular layer and (2) the establishment of mGluR signaling and associated removal of surplus climbing fibers from PCs.
findings strongly suggest that CLDND1 is a direct RORalpha target
TRIB3 promotes acute promyelocytic leukemia progression through stabilization of the oncoprotein PML-RARalpha and inhibition of p53-mediated senescence.
Retinoid-related orphan receptor alpha (RORalpha) reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMP-activated protein kinase (AMPK), therefore, both RORalpha and AMPK are potential targets for the intervention and therapy in gastric carcinoma.
the RAR-related orphan receptor-a gene (RORA) and the Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha gene (PPARGC1A or PGC-1alpha) were significantly associated with the Li response. Our results suggest genetic associations between Li response and these two close biological partners: PPARGC1A and RORA involved in circadian rhythms and bioenergetics processes in Li response
The present study is to determine if any relation exists between RORA rs11639084 and rs4774388 gene polymorphisms on the individual susceptibility of multiple sclerosis.
ROR-alpha may regulate signaling receptor activity, and transmembrane transport activity through its potential target genes.
Association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China.
this animal model study suggests that the NR, RORalpha4, has a critical regulatory role in the phenotype associated with decreased subcutaneous fat deposition, fatty liver and impaired glucose tolerance.
The RORA intronic SNP rs11632098 was associated with greater odds of reporting depressive symptoms in older adults.
A common SNP in the RORA gene (rs2899663) was associated with a 21% reduced odds of placental abruption.
study reports cloning and expression pattern of zebrafish ROR alpha orthologues rora1 and rora2; both rora1 and rora2 are spatially expressed in the retina and tectum; expression of rora2 was further observed in the cerebellum
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.
nuclear receptor ROR-alpha
, RAR-related orphan receptor A
, RAR-related orphan receptor alpha
, nuclear receptor RZR-alpha
, nuclear receptor subfamily 1 group F member 1
, retinoic acid receptor-related orphan receptor alpha
, retinoid-related orphan receptor alpha
, thyroid hormone nuclear receptor alpha variant 4
, transcription factor RZR-alpha
, retinoid-related orphan receptor alpha 2
, retinoid-related orphan receptor-alpha