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anti-Human RORA Antibodies:
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Human Polyclonal RORA Primary Antibody for ICC, IF - ABIN4350939
Benderdour, Fahmi, Beaudet, Fernandes, Shi: Nuclear receptor retinoid-related orphan receptor α1 modulates the metabolic activity of human osteoblasts. in Journal of cellular biochemistry 2011
Show all 2 Pubmed References
Cow (Bovine) Polyclonal RORA Primary Antibody for WB - ABIN2776008
Tordjman, Leroyer, Chauvet, Quette, Chauvet, Tomkiewicz, Chapron, Barouki, Forest, Aggerbeck, Antoine: Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione. in The Journal of biological chemistry 2007
CYP11A1 (show CYP11A1 Antibodies)- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
The expression RORalpha is significantly elevated under hypoxic conditions in keratinocytes in an HIF-1alpha (show HIF1A Antibodies) dependent manner.
Retinoid-related orphan receptor alpha-regulated development of the mouse cerebellum has a distinct critical period for (1) lengthening Purkinje cell (PC) primary dendrite stems and the eventual increase in the thickness of the molecular layer and (2) the establishment of mGluR (show GRM8 Antibodies) signaling and associated removal of surplus climbing fibers from PCs.
findings strongly suggest that CLDND1 is a direct RORalpha target
TRIB3 (show TRIB3 Antibodies) promotes acute promyelocytic leukemia (show PML Antibodies) progression through stabilization of the oncoprotein PML (show PML Antibodies)-RARalpha (show RARA Antibodies) and inhibition of p53 (show TP53 Antibodies)-mediated senescence.
Retinoid-related orphan receptor alpha (RORalpha) reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)), therefore, both RORalpha and AMPK (show PRKAA1 Antibodies) are potential targets for the intervention and therapy in gastric carcinoma.
the RAR-related orphan receptor-a gene (RORA) and the Peroxisome Proliferator-Activated Receptor Gamma (show PPARG Antibodies), Coactivator 1 Alpha gene (PPARGC1A (show PPARGC1A Antibodies) or PGC-1alpha (show PPARGC1A Antibodies)) were significantly associated with the Li response. Our results suggest genetic associations between Li response and these two close biological partners: PPARGC1A (show PPARGC1A Antibodies) and RORA involved in circadian rhythms and bioenergetics processes in Li response
The present study is to determine if any relation exists between RORA rs11639084 and rs4774388 gene polymorphisms on the individual susceptibility of multiple sclerosis.
Association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China.
The RORA intronic SNP rs11632098 was associated with greater odds of reporting depressive symptoms in older adults.
study reports cloning and expression pattern of zebrafish ROR alpha orthologues rora1 and rora2; both rora1 and rora2 are spatially expressed in the retina and tectum; expression of rora2 was further observed in the cerebellum
RORalpha/gamma are important therapeutic targets for cutaneous inflammation; RORa and RORg (show RORC Antibodies) have roles in inflammation in mouse models of atopic dermatitis and acute irritant dermititis
Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 (show TPM1 Antibodies) cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1 (show ARNTL Antibodies), Rev-erbalpha (show NR1D1 Antibodies), Roralpha).
RORalpha inhibits PPARgamma (show PPARG Antibodies)-mediated transcriptional activity by interacting with HDAC3 (show HDAC3 Antibodies) and competing for the promoters of lipogenic genes.
that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E (show SEMA3E Antibodies)-mediated neurovascular coupling in pathological retinal angiogenesis
The deficiency of LXRalpha (show NR1H3 Antibodies) decreased glucose uptake after MI, resulting in a metabolic shift that suppressed glucose metabolism, which was in association with adverse cardiac remodeling.
Data suggest that inflammatory response in macrophages, white adipocytes, and white adipose tissue in obese mice, includes up-regulation of expression of Rora; in adipose tissue, overexpression of Rora or treatment with Rora agonist enhances expression of cytokines, promotes macrophage infiltration, up-regulates expression of genes involved in ER stress response, and enhances signaling seen in unfolded protein response.
these findings reveal that RORalpha regulates macrophage M2 polarization via activation of AMPKalpha (show GRK4 Antibodies)
RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3 (show SOCS3 Antibodies)-dependent inflammation
This study showed that spontaneous Rora mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.
nuclear receptor ROR-alpha
, RAR-related orphan receptor A
, RAR-related orphan receptor alpha
, nuclear receptor RZR-alpha
, nuclear receptor subfamily 1 group F member 1
, retinoic acid receptor-related orphan receptor alpha
, retinoid-related orphan receptor alpha
, thyroid hormone nuclear receptor alpha variant 4
, transcription factor RZR-alpha
, retinoid-related orphan receptor alpha 2
, retinoid-related orphan receptor-alpha