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|Antigen||Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Antibodies|
|Epitope||AA 120-155 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CDKN1A antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-CDKN1A AntibodyTarget Details CDKN1A Application Details Handling References for anti-CDKN1A antibody (ABIN672606) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from mouse P21|
Target Details CDKN1AProduct Details anti-CDKN1A Antibody Application Details Handling References for anti-CDKN1A antibody (ABIN672606) Images back to top
|Alternative Name||CDKN1A (CDKN1A Antibody Abstract)|
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).
Subcellular location: Cytoplasm, Nucleus
Synonyms: P21, CDKI, CIP1, SDI1, Waf1, mda6, CAP2, Cdkn1, p21WAF, p21Cip1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, Cdkn1a
|Pathways||p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy|
Application DetailsProduct Details anti-CDKN1A Antibody Target Details CDKN1A Handling References for anti-CDKN1A antibody (ABIN672606) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-CDKN1A Antibody Target Details CDKN1A Application Details References for anti-CDKN1A antibody (ABIN672606) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-CDKN1A antibody (ABIN672606)Product Details anti-CDKN1A Antibody Target Details CDKN1A Application Details Handling Images back to top
|Product cited in:||
Jiang, Miao, Xiao, Zhang, Hu: "DAPT in the control of human hair follicle stem cell proliferation and differentiation." in: Post?py dermatologii i alergologii, Vol. 31, Issue 4, pp. 201-6, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Wu, Wang, Zong, Chen, Wang, Xu, Cui: "Simultaneous evaluation of p53 and p21 expression level for early cancer diagnosis using SERS technique." in: The Analyst, Vol. 138, Issue 12, pp. 3450-6, 2013
Li, Dai, Ye, Wang, Xiao, Zheng, Chen, Luo, Liu: "Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition." in: Cancer cell international, Vol. 12, Issue 1, pp. 49, 2013 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Chen, Shi, Liu, Fang, Zhang, Zhao: "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." in: BMC cancer, Vol. 12, pp. 464, 2012 Method employed by authors: Western Blotting (WB) (1:1000, Sample species: Human).
ImagesProduct Details anti-CDKN1A Antibody Target Details CDKN1A Application Details Handling References for anti-CDKN1A antibody (ABIN672606) back to top