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Data indicate lysine acetyltransferase 2B (KAT2B) as a susceptibility gene for kidney and heart disease in adducin 3 (gamma (show ADD3 Proteins)) protein (ADD3 (show ADD3 Proteins))-associated disorders.
PCAF/GCN5 (show KAT2A Proteins)-mediated lysine 163 acetylation of RPA1 (show RPA1 Proteins) is crucial for nucleotide excision repair.
PCAF and ADA3 (show TADA3 Proteins) transcriptionally regulate PACS1 and PACS1 is a key regulator of BAX (show BAX Proteins)/BAK (show BAK1 Proteins) oligomerization and the intrinsic (mitochondrial) pathway to apoptosis.
Knockdown of the acetyltransferase Kat2b erases H3K9ac signals, disrupts Sox2 (show SOX2 Proteins) binding, and fails the differentiation during human neuroectodermal commitment.
GCN5 (show KAT2A Proteins) upregulation is especially common in UCCs. GCN5 (show KAT2A Proteins) knockdown impeded growth of specific UCCs, whereas PCAF knockdown elicited minor effects.
histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of mesenchymal stem cells.
cancer associated fibroblasts (CAFs) promoted hepatocellular cancer (HCC) growth via IL-6/STAT3/AKT pathway and TIMP-1 over-expression driven by IL-6/STAT3 pathway in HCC cells brought in more CAFs through activating liver fibroblasts.
These results uncover p300 (show EP300 Proteins) as a direct target of mTORC1 and suggest that the mTORC1-p300 (show EP300 Proteins) pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism
TNF-alpha (show TNF Proteins) and LPS (show IRF6 Proteins) promoted the interaction between MKL1 and PCAF.
PCAF is a novel modulator of autophagy in hepatocellular carcinoma.
These results uncover p300 (show NOTCH1 Proteins) as a direct target of mTORC1 and suggest that the mTORC1-p300 (show NOTCH1 Proteins) pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism
The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy.
Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 (show NOTCH1 Proteins) and PCAF to the NKX2.5 (show NKX2-5 Proteins), beta-MHC (show MYH7 Proteins), Cx43 (show GJA1 Proteins) promoters and attenuated H3K9 hyperacetylation.
Gcn5 (show KAT2A Proteins) and PCAF repress IFN-beta (show IFNB1 Proteins) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (show TBK1 Proteins) in the cytoplasm.
PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha. PCAF in the obese mouse liver greatly represses gluconeogenic enzyme activation and glucose production and improves glucose homeostasis and insulin (show INS Proteins) sensitivity.
Study reveals that Gcn5 (show KAT2A Proteins)/PCAF facilitate adipogenesis through regulation of PPARgamma (show PPARG Proteins) expression and regulate brown adipogenesis by influencing Prdm16 (show PRDM16 Proteins) expression.
KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 (show FOXP3 Proteins) via Sin3-HDAC (show HDAC3 Proteins)/PCAF pathway and, thus, immune activation.
PCAF is necessary for axonal regeneration and also promotes regeneration after spinal cord injury.
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
, histone acetyltransferase KAT2B
, CREBBP-associated factor
, histone acetylase PCAF
, histone acetyltransferase PCAF
, lysine acetyltransferase 2B
, K(lysine) acetyltransferase 2B